The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis.

The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis. Research Abstract Details 

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The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis. Abstract Text:

A Rebbaa,X Zheng,F Chu,B L Mirkin,

The present study was undertaken to determine the significance of histone acetylation versus DNA damage in drug-induced irreversible growth arrest (senescence) and apoptosis. Cellular treatment with the DNA-damaging drugs doxorubicin and cisplatin or with the histone deacetylase inhibitor trichostatin A, led to the finding that all the three drugs induced senescence at concentrations significantly lower than those required for apoptosis. However, only doxorubicin and cisplatin induced activation of H2AX, a marker for double-strand break formation. Interestingly, this occurred mainly at apoptosis and not senescence-inducing drug concentrations, suggesting that non-DNA-damage pathways may be implicated in induction of senescence by these drugs. In agreement with this, chromatin immunoprecipitation experiments indicated that doxorubicin was able to induce acetylation of histone H3 at the promoter of p21/WAF1 only at senescence-inducing concentrations. Collectively, these findings suggest that alteration of chromatin structure by cytotoxic drugs may represent a key mediator of senescence.

The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis. Publishing Authors By Initials

A Rebbaa,X Zheng,F Chu,BL Mirkin,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell death and differentiation

VOLUME: 13

Page Numbers: 1960-7

Journal Abbreviation: Cell Death Differ.

ISSN: 1350-9047

DAY: 24

MONTH: 03

YEAR: 2006

The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis. Information

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LANGUAGE: eng

NlmUniqueID: 9437445

The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: pharmacology

Chemical & Substance for Abstract: The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis.

AFFILIATION: Children's Memorial Research Center, Children's Memorial Hospital, Department of Pediatrics, Northwestern University, Chicago, IL 60614, USA. arebbaa@childrensmemorial.org

Country: England

AGENCY: United States NCI

GRANT: 1R01 CA096616-01A1

ACRONYM: CA

MEDLINETA: Cell Death Differ

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