The role of heme oxygenase-1 in pulmonary disease.

The role of heme oxygenase-1 in pulmonary disease. Research Abstract Details 

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The role of heme oxygenase-1 in pulmonary disease. Abstract Text:

Laura E Fredenburgh,Mark A Perrella,S Alex Mitsialis,

Heme oxygenase (HO)-1, the inducible isoform of heme oxygenase, is a cytoprotective enzyme that plays a central role in the defense against oxidative and inflammatory insults in the lung. HO-1 catalyzes the degradation of heme, a potent oxidant, into biliverdin, iron, and carbon monoxide (CO). These downstream products of heme catabolism have recently been found to mediate the antioxidant, antiapoptotic, antiproliferative, vasodilatory, and anti-inflammatory properties of HO-1. Although absence of HO-1 is rare in humans, a number of HO-1 promoter polymorphisms have been identified that may influence HO-1 expression in vivo and lead to disease states. This review will summarize studies that implicate HO-1 and heme metabolites in the pathophysiology of pulmonary disease and discuss recent advances in the therapeutic applications of HO-1.

The role of heme oxygenase-1 in pulmonary disease. Publishing Authors By Initials

LE Fredenburgh,MA Perrella,SA Mitsialis,

For similar cardiovascular diseases: vascular diseases research abstracts see: cardiovascular diseases: vascular diseases research

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The role of heme oxygenase-1 in pulmonary disease. Journal Published:

PUBLICATION TYPE: Review

Journal: American journal of respiratory cell and molecular

VOLUME: 36

Page Numbers: 158-65

Journal Abbreviation: Am. J. Respir. Cell Mol. Biol.

ISSN: 1044-1549

DAY: 15

MONTH: 09

YEAR: 2006

The role of heme oxygenase-1 in pulmonary disease. Information

Number of References: 93

LANGUAGE: eng

NlmUniqueID: 8917225

The role of heme oxygenase-1 in pulmonary disease. Keywords Mesh Terms:

KEYWORDS: Vascular Diseases

MESH TERMS: therapy

Chemical & Substance for Abstract: The role of heme oxygenase-1 in pulmonary disease. Information

Substance Name: Heme Oxygenase-1

Registry Number: EC 1.14.99.3

Grant and Affiliation Information for The role of heme oxygenase-1 in pulmonary disease.

AFFILIATION: Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. lfredenburgh@partners.org

Country: United States

AGENCY: United States NHLBI

GRANT: T32 HL007633-21

ACRONYM: HL

MEDLINETA: Am J Respir Cell Mol Biol

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