The role of GSK3 in glucose homeostasis and the development of insulin resistance.

The role of GSK3 in glucose homeostasis and the development of insulin resistance. Research Abstract Details 

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The role of GSK3 in glucose homeostasis and the development of insulin resistance. Abstract Text:

Jongsoon Lee,Myung-Sunny Kim,

GSK3 has been implicated in the development of insulin resistance, primarily based on its role in regulation of glycogen synthesis. However, GSK3 is involved in many other important signaling cascades which may regulate glucose homeostasis and the development of insulin resistance. In addition, GSK3 is composed of two isoforms, GSK3alpha and beta, which do not completely share their physiological roles, and this raises a possibility that GSK3alpha and beta may function differently in glucose homeostasis. In this review, we will give an overview to examine potential mechanisms for the roles of GSK3 in the development of insulin resistance.

The role of GSK3 in glucose homeostasis and the development of insulin resistance. Publishing Authors By Initials

J Lee,MS Kim,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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The role of GSK3 in glucose homeostasis and the development of insulin resistance. Journal Published:

PUBLICATION TYPE: Review

Journal: Diabetes research and clinical practice

VOLUME: 77 Suppl 1

Page Numbers: S49-57

Journal Abbreviation: Diabetes Res. Clin. Pract.

ISSN: 0168-8227

DAY: 2

MONTH: 05

YEAR: 2007

The role of GSK3 in glucose homeostasis and the development of insulin resistance. Information

Number of References: 88

LANGUAGE: eng

NlmUniqueID: 8508335

The role of GSK3 in glucose homeostasis and the development of insulin resistance. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: The role of GSK3 in glucose homeostasis and the development of insulin resistance. Information

Substance Name: Glycogen Synthase Kinase 3

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for The role of GSK3 in glucose homeostasis and the development of insulin resistance.

AFFILIATION: Joslin Diabetes Center, Harvard Medical School, Boston, USA. jongsoon.lee@joslin.harvard.edu

Country: Ireland

AGENCY: United States NIDDK

GRANT: DK63225

ACRONYM: DK

MEDLINETA: Diabetes Res Clin Pract

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