The role of functional imaging in the diagnosis and management of late normal tissue injury.

The role of functional imaging in the diagnosis and management of late normal tissue injury. Research Abstract Details 

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The role of functional imaging in the diagnosis and management of late normal tissue injury. Abstract Text:

Elizabeth S Evans,Carol A Hahn,Zafer Kocak,Su-Min Zhou,Lawrence B Marks,

Normal tissue injury after radiation therapy (RT) can be defined based on either clinical symptoms or laboratory/radiologic tests. In the research setting, functional imaging (eg, single-photon emission computed tomography [SPECT], positron-emission tomography [PET], and magnetic resonance imaging [MRI]) is useful because it provides objective quantitative data such as metabolic activity, perfusion, and soft-tissue contrast within tissues and organs. For RT-induced lung, heart, and parotid gland injury, pre- and post-RT SPECT images can be compared with the dose- and volume-dependent nature of regional injury. In the brain, SPECT can detect changes in perfusion and blood flow post-RT, and PET can detect metabolic changes, particularly to regions of the brain that have received doses above 40 to 50 Gy. On MRI, changes in contrast-enhanced images, T(1) and T(2) relaxation times, and pulmonary vascular resistance at different intervals pre- and post-RT show its ability to detect and distinguish different phases of radiation pneumonitis. Similarly, conventional and diffusion-weighted MRI can be used to differentiate between normal tissue edema, necrosis, and tumor in the irradiated brain, and magnetic resonance spectroscopy can measure changes in compounds, indicative of membrane and neuron disruption. The use of functional imaging is a powerful tool for early detection of RT-induced normal tissue injury, which may be related to long-term clinically significant injury.

The role of functional imaging in the diagnosis and management of late normal tissue injury. Publishing Authors By Initials

ES Evans,CA Hahn,Z Kocak,SM Zhou,LB Marks,

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The role of functional imaging in the diagnosis and management of late normal tissue injury. Journal Published:

PUBLICATION TYPE: Review

Journal: Seminars in radiation oncology

VOLUME: 17

Page Numbers: 72-80

Journal Abbreviation:

ISSN: 1053-4296

DAY: 3

MONTH: Apr

YEAR: 2007

The role of functional imaging in the diagnosis and management of late normal tissue injury. Information

Number of References: 89

LANGUAGE: eng

NlmUniqueID: 9202882

The role of functional imaging in the diagnosis and management of late normal tissue injury. Keywords Mesh Terms:

KEYWORDS: Tomography, Emission-Computed, Single-Ph

MESH TERMS: adverse effects

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Grant and Affiliation Information for The role of functional imaging in the diagnosis and management of late normal tissue injury.

AFFILIATION: Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA69579

ACRONYM: CA

MEDLINETA: Semin Radiat Oncol

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