The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development.

The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. Research Abstract Details 

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The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. Abstract Text:

Richard Grose,Vera Fantl,Sabine Werner,Athina-Myrto Chioni,Monika Jarosz,Robert Rudling,Barbara Cross,Ian R Hart,Clive Dickson,

The epithelial isoform of fibroblast growth factor receptor 2 (Fgfr2b) is essential for embryogenesis, and Fgfr2b-null mice die at birth. Using Cre-Lox transgenics to delete Fgfr2b in cells expressing keratin 5, we show that mice lacking epidermal Fgfr2b survive into adulthood but display striking abnormalities in hair and sebaceous gland development. Epidermal hyperthickening develops with age, and 10% of mutant mice develop spontaneous papillomas, demonstrating the role of Fgfr2b in post-natal skin development and in adult skin homeostasis. Mice lacking epithelial Fgfr2b show great sensitivity to chemical carcinogenic insult, displaying several oncogenic ha-ras mutations with dramatic development of papillomas and squamous cell carcinomas. Mutant mice have increased inflammation in the skin, with increased numbers of macrophages and gammadeltaT cells with abnormal morphology. Mutant skin shows several changes in gene expression, including enhanced expression of the pro-inflammatory cytokine interleukin 18 and decreased expression of Serpin a3b, a potential tumor suppressor. Thus we describe a novel role of Fgfr2b and provide the first evidence of a tyrosine kinase receptor playing a tumor suppressive role in the skin.

The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. Publishing Authors By Initials

R Grose,V Fantl,S Werner,AM Chioni,M Jarosz,R Rudling,B Cross,IR Hart,C Dickson,

For similar integumentary system: skin research abstracts see: integumentary system: skin research

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The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The EMBO journal

VOLUME: 26

Page Numbers: 1268-78

Journal Abbreviation: EMBO J.

ISSN: 0261-4189

DAY: 15

MONTH: 02

YEAR: 2007

The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8208664

The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. Keywords Mesh Terms:

KEYWORDS: Skin

MESH TERMS: physiopathology

Chemical & Substance for Abstract: The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. Information

Substance Name: Receptor, Fibroblast Growth Factor, Type

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development.

AFFILIATION: Centre for Tumour Biology, Institute of Cancer, Bart's & The London, Queen Mary's School of Medicine & Dentistry, London, UK. r.p.grose@qmul.ac.uk

Country: England

AGENCY: United Kingdom Wellcome T

GRANT: 076678

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MEDLINETA: EMBO J

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