The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates.

The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates. Research Abstract Details 

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The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates. Abstract Text:

Aftab A Ansari,Lara E Pereira,Ann E Mayne,Nattawat Onlamoon,Kovit Pattanapanyasat,Kazuyasu Mori,F Villinger,

Autoantibodies appear in the sera of rhesus macaques following SIV infection. The present study was conducted to examine the role of viral load, antiviral chemotherapy and stage of disease on the titers of such autoantibodies and the spectrum of autoantigens that become the target of such autoimmune responses. In addition, the role of regulatory T cells (Tregs) was also examined. Results of these studies showed that the highest autoantibody titers were noted in animals with lower relative plasma viral loads with a wider spectrum of autoantigens that are the target of such responses as compared with lower autoantibody titers in animals with relatively higher plasma viral loads and a narrower spectrum of autoantigens. Short-term antiviral chemotherapy did not influence the titers of autoantibodies. While there was a gradual decrease in the frequency and absolute number of Tregs, the levels of Tregs was inversely correlated with viral load and lower autoantibody titers. The mechanisms for these differences remain unknown and suggest complex relationships exist between levels of immunosuppression, autoimmune response, homeostatic proliferation and the spectrum of autoantigens that become the target of such autoimmune responses.

The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates. Publishing Authors By Initials

AA Ansari,LE Pereira,AE Mayne,N Onlamoon,K Pattanapanyasat,K Mori,F Villinger,

For similar investigative techniques: clinical laboratory techniques: microbiological techniques: viral load research abstracts see: investigative techniques: clinical laboratory techniques: microbiological techniques: viral load research

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The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of autoimmunity

VOLUME: 28

Page Numbers: 152-9

Journal Abbreviation:

ISSN: 0896-8411

DAY: 26

MONTH: 03

YEAR: 2007

The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates. Information

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LANGUAGE: eng

NlmUniqueID: 8812164

The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates. Keywords Mesh Terms:

KEYWORDS: Viral Load

MESH TERMS: immunology

Chemical & Substance for Abstract: The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates. Information

Substance Name: Autoantigens

Registry Number: 0

Grant and Affiliation Information for The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates.

AFFILIATION: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. pathaaa@emory.edu

Country: England

AGENCY: United States NCRR

GRANT: R24 RR-16988

ACRONYM: RR

MEDLINETA: J Autoimmun

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