The role of cytokines in a Porphyromonas gingivalis-induced murine abscess model.

The role of cytokines in a Porphyromonas gingivalis-induced murine abscess model. Research Abstract Details 

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The role of cytokines in a Porphyromonas gingivalis-induced murine abscess model. Abstract Text:

J Alayan,E Gemmell,P Ford,S Hamlet,P S Bird,S Ivanovski,C S Farah,J Alayan,E Gemmell,P Ford,S Hamlet,P S Bird,S Ivanovski,C S Farah,

INTRODUCTION: Porphyromonas gingivalis is an important periodontopathic bacterium that is strongly associated with periodontal disease and is part of human dental plaque. Periodontal disease results from the interaction of the host with bacterial products, and T-cell-derived cytokines remain critical in the immunoregulation of periodontal disease. METHODS: The aim of this study was to examine the role of T helper type 1 [interleukin-12p40 (IL-12p40), interferon-gamma, tumour necrosis factor (TNF)] and type 2 (IL-4, IL-10) cytokines in the immune response to a subcutaneous challenge with P. gingivalis using a well-established murine abscess model, in genetically modified cytokine-specific knockout mice. RESULTS: IL-12p40(-/-) mice exhibited more advanced tissue destruction and a reduced inflammatory cell infiltrate after subcutaneous P. gingivalis challenge. Deficiency of IL-4 or IL-10 did not result in increased susceptibility to P. gingivalis-mediated tissue destruction. Furthermore, TNF deficiency appeared to reduce local tissue destruction. Interestingly, serum-specific antibodies suggested a strong T helper type 2 response. CONCLUSION: The results of our study indicate an important role for IL-12 in a primary P. gingivalis subcutaneous challenge.

The role of cytokines in a Porphyromonas gingivalis-induced murine abscess model. Publishing Authors By Initials

J Alayan,E Gemmell,P Ford,S Hamlet,PS Bird,S Ivanovski,CS Farah,J Alayan,E Gemmell,P Ford,S Hamlet,PS Bird,S Ivanovski,CS Farah,

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The role of cytokines in a Porphyromonas gingivalis-induced murine abscess model. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Oral microbiology and immunology

VOLUME: 22

Page Numbers: 304-12

Journal Abbreviation: Oral Microbiol. Immunol.

ISSN: 0902-0055

DAY: 6

MONTH: Oct

YEAR: 2007

The role of cytokines in a Porphyromonas gingivalis-induced murine abscess model. Information

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LANGUAGE: eng

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AFFILIATION: Oral Biology and Pathology, School of Dentistry, University of Queensland, Brisbane, QLD, Australia.

Country: Denmark

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MEDLINETA: Oral Microbiol Immunol

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