The CXC chemokine family is a pleiotropic family of cytokines that are involved in promoting the trafficking of various leukocytes, in regulating angiogenesis and vascular remodeling, and in promoting the mobilization and trafficking of mesenchymal progenitor cells such as fibrocytes. These functions of CXC chemokines are important in the pathogenesis of pulmonary fibrosis and other fibroproliferative disorders. In this Review, we discuss the biology of CXC chemokine family members, specifically as it relates to their role in regulating vascular remodeling and trafficking of circulating mesenchymal progenitor cells (also known as fibrocytes) in pulmonary fibrosis.
The role of CXC chemokines in pulmonary fibrosis. Publishing Authors By Initials
The role of CXC chemokines in pulmonary fibrosis. Journal Published:
PUBLICATION TYPE: Review
Journal: The Journal of clinical investigation
VOLUME: 117
Page Numbers: 549-56
Journal Abbreviation: J. Clin. Invest.
ISSN: 0021-9738
DAY: 3
MONTH: Mar
YEAR: 2007
The role of CXC chemokines in pulmonary fibrosis. Information
Number of References: 106
LANGUAGE: eng
NlmUniqueID: 7802877
The role of CXC chemokines in pulmonary fibrosis. Keywords Mesh Terms:
KEYWORDS: Stem Cells
MESH TERMS: physiology
Chemical & Substance for Abstract: The role of CXC chemokines in pulmonary fibrosis. Information
Substance Name: Chemokines, CXC
Registry Number: 0
Grant and Affiliation Information for The role of CXC chemokines in pulmonary fibrosis.
AFFILIATION: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. strieter@virginia.edu
Country: United States
AGENCY: United States NHLBI
GRANT: P50 HL67665
ACRONYM: HL
MEDLINETA: J Clin Invest
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