The role of CCL22/macrophage-derived chemokine in allergic rhinitis.

The role of CCL22/macrophage-derived chemokine in allergic rhinitis. Research Abstract Details 

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The role of CCL22/macrophage-derived chemokine in allergic rhinitis. Abstract Text:

Mitsuru Yanai,Keisuke Sato,Naoko Aoki,Yumi Takiyama,Kensuke Oikawa,Hiroya Kobayashi,Shoji Kimura,Yasuaki Harabuchi,Masatoshi Tateno,Mitsuru Yanai,Keisuke Sato,Naoko Aoki,Yumi Takiyama,Kensuke Oikawa,Hiroya Kobayashi,Shoji Kimura,Yasuaki Harabuchi,Masatoshi Tateno,Mitsuru Yanai,Keisuke Sato,Naoko Aoki,Yumi Takiyama,Kensuke Oikawa,Hiroya Kobayashi,Shoji Kimura,Yasuaki Harabuchi,Masatoshi Tateno,

Dendritic cells (DCs) are considered to be the most powerful antigen-presenting cells (APCs). DCs are thought to be associated with Th1 or Th2 polarization and with polarization-induced disease such as atopic dermatitis, asthma and allergic rhinitis, but its mechanism is not well known. In this study, we analyzed the mRNA expression of DCs between birch pollen allergic rhinitis and healthy controls by using cDNA array. We found that the expressions of CCL22/macrophage-derived chemokine (MDC) differed significantly. We also revealed that CCL22/MDC production was higher in patients than in healthy donors. By chemotaxis assay, CCL22/MDC can enhance the migration of patient's T cells rather than those of healthy controls. Surface marker analysis of migrated cells revealed that the most of migrated cells expressed CCR4, which were considered to be Th2 cells. Furthermore, CD1a(+) CD83(+) cells located in the nasal mucosa expressed CCL22/MDC in vivo. To the best of our knowledge, this is the first report clearly indicating the role of CCL22/MDC in allergic rhinitis.

The role of CCL22/macrophage-derived chemokine in allergic rhinitis. Publishing Authors By Initials

M Yanai,K Sato,N Aoki,Y Takiyama,K Oikawa,H Kobayashi,S Kimura,Y Harabuchi,M Tateno,M Yanai,K Sato,N Aoki,Y Takiyama,K Oikawa,H Kobayashi,S Kimura,Y Harabuchi,M Tateno,M Yanai,K Sato,N Aoki,Y Takiyama,K Oikawa,H Kobayashi,S Kimura,Y Harabuchi,M Tateno,

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The role of CCL22/macrophage-derived chemokine in allergic rhinitis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical immunology (Orlando, Fla.)

VOLUME: 125

Page Numbers: 291-8

Journal Abbreviation: Clin. Immunol.

ISSN: 1521-6616

DAY: 29

MONTH: 10

YEAR: 2007

The role of CCL22/macrophage-derived chemokine in allergic rhinitis. Information

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LANGUAGE: eng

NlmUniqueID: 100883537

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Grant and Affiliation Information for The role of CCL22/macrophage-derived chemokine in allergic rhinitis.

AFFILIATION: Department of Pathology, Asahikawa Medical College, Hokkaido, Japan; Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical College, Hokkaido, Japan.

Country: United States

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MEDLINETA: Clin Immunol

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