The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart.

The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Research Abstract Details 

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The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Abstract Text:

Hiromitsu Takagi,Yutaka Matsui,Junichi Sadoshima,

Autophagy is a major mechanism for degrading long-lived cytosolic proteins and the only known pathway for degrading organelles. Autophagy is activated by many forms of stress, including nutrient and energy starvation, oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, and infections. Although autophagy recycles amino acids and fatty acids to produce energy and removes damaged organelles, thereby playing an essential role in cell survival, inappropriate activation of autophagy leads to cell death. In the heart, activation of autophagy can be observed in response to nutrient starvation, ischemia/reperfusion, and heart failure. In this review, the signaling mechanism and the functional significance of autophagy during myocardial ischemia and reperfusion are discussed.

The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Publishing Authors By Initials

H Takagi,Y Matsui,J Sadoshima,

For similar surgical procedures, operative: cardiovascular surgical procedures: reperfusion research abstracts see: surgical procedures, operative: cardiovascular surgical procedures: reperfusion research

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The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Journal Published:

PUBLICATION TYPE: Review

Journal: Antioxidants & redox signaling

VOLUME: 9

Page Numbers: 1373-81

Journal Abbreviation: Antioxid. Redox Signal.

ISSN: 1523-0864

DAY: 3

MONTH: Sep

YEAR: 2007

The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Information

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LANGUAGE: eng

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The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Keywords Mesh Terms:

KEYWORDS: Reperfusion

MESH TERMS: physiopathology

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Grant and Affiliation Information for The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart.

AFFILIATION: Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL73048

ACRONYM: HL

MEDLINETA: Antioxid Redox Signal

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