The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia.

The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Research Abstract Details 

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The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Abstract Text:

Ronjon Chakraverty,Megan Sykes,

After allogeneic blood or bone marrow transplantation, donor T cells interact with a distorted antigen-presenting cell (APC) environment in which some, but not all, host APCs are replaced by APCs from the donor. Significantly, host APCs are required for the priming of acute graft-versus-host disease (GVHD). Donor APCs play a lesser role in the induction of acute GVHD despite their predicted capacity to cross-present host antigens. In contrast, donor APCs may play a role in perpetuating the tissue injury observed in chronic GVHD. Host APCs are also required for maximal graft-versus-leukemia responses. Recent studies have suggested potential strategies by which the continued presence of host APCs can be exploited to prime strong donor immunity to tumors without the induction of GVHD.

The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Publishing Authors By Initials

R Chakraverty,M Sykes,

For similar animals: chordata: vertebrates: mammals: primates: haplorhini: catarrhini: hominidae: humans research abstracts see: animals: chordata: vertebrates: mammals: primates: haplorhini: catarrhini: hominidae: humans research

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The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Blood

VOLUME: 110

Page Numbers: 9-17

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 27

MONTH: 02

YEAR: 2007

The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Information

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LANGUAGE: eng

NlmUniqueID: 7603509

The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Keywords Mesh Terms:

KEYWORDS: Humans

MESH TERMS: immunology

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Grant and Affiliation Information for The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia.

AFFILIATION: Department of Hematology, University College London, London, United Kingdom.

Country: United States

AGENCY: United States NCI

GRANT: R01 R01 CA79989

ACRONYM: CA

MEDLINETA: Blood

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