The risk of malarial infections and disease in Papua New Guinean children.

The risk of malarial infections and disease in Papua New Guinean children. Research Abstract Details 

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The risk of malarial infections and disease in Papua New Guinean children. Abstract Text:

In a treatment re-infection study of 206 Papua New Guinean school children, we examined risk of reinfection and symptomatic malaria caused by different Plasmodium species. Although children acquired a similar number of polymerase chain reaction-detectable Plasmodium falciparum and P. vivax infections in six months of active follow-up (P. falciparum = 5.00, P. vivax = 5.28), they were 21 times more likely to develop symptomatic P. falciparum malaria (1.17/year) than P. vivax malaria (0.06/year). Children greater than nine years of age had a reduced risk of acquiring P. vivax infections of low-to-moderate (>150/microL) density (adjusted hazard rate [AHR] = 0.65 and 0.42), whereas similar reductions in risk with age of P. falciparum infection was only seen for parasitemias > 5,000/microL (AHR = 0.49) and symptomatic episodes (AHR = 0.51). Infection and symptomatic episodes with P. malariae and P. ovale were rare. By nine years of age, children have thus acquired almost complete clinical immunity to P. vivax characterized by a very tight control of parasite density, whereas the acquisition of immunity to symptomatic P. falciparum malaria remained incomplete. These observations suggest that different mechanisms of immunity may be important for protection from these malaria species.

The risk of malarial infections and disease in Papua New Guinean children. Publishing Authors By Initials

For similar organic chemicals: hydrocarbons: terpenes: sesquiterpenes research abstracts see: organic chemicals: hydrocarbons: terpenes: sesquiterpenes research

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The risk of malarial infections and disease in Papua New Guinean children. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of tropical medicine and hygi

VOLUME: 76

Page Numbers: 997-1008

Journal Abbreviation: Am. J. Trop. Med. Hyg.

ISSN: 0002-9637

DAY: 3

MONTH: Jun

YEAR: 2007

The risk of malarial infections and disease in Papua New Guinean children. Information

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LANGUAGE: eng

NlmUniqueID: 370507

The risk of malarial infections and disease in Papua New Guinean children. Keywords Mesh Terms:

KEYWORDS: Sesquiterpenes

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: The risk of malarial infections and disease in Papua New Guinean children. Information

Substance Name: artesunate

Registry Number: 83507-69-1

Grant and Affiliation Information for The risk of malarial infections and disease in Papua New Guinean children.

AFFILIATION: Papua New Guinea Institute of Medical Research, PO Box 378, Madang, MAD 511, Papua New Guinea.

Country: United States

AGENCY: United States NIAID

GRANT: AI07024

ACRONYM: AI

MEDLINETA: Am J Trop Med Hyg

REFSOURCE: Am J Trop Med Hyg. 2007 Jun;76(6):995-6

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