The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway.

The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway. Research Abstract Details 

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The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway. Abstract Text:

Seiyu Imoto,Kenji Sugiyama,Tetsuya Yamamoto,Tadashi Matsuda,

Bone morphogenetic proteins (BMPs) play central roles in differentiation, development, and physiologic tissue remodeling. Recently, we have demonstrated that a protein inhibitor of activated STAT, PIASy, suppresses TGF-beta signaling by interacting with Sma and MAD-related protein 3 (Smad3). In this study, we examined a PIASy-dependent inhibitory effect on BMP signaling. PIASy expression was induced by BMP-2 stimulation and suppressed BMP-2-dependent Smad activity in hepatoma cells. Furthermore, BMP-2-regulated Smads directly bound to PIASy. We also demonstrated that the RING domain of PIASy played an important role in PIASy-mediated suppression of Smad activity. We here provide evidence that the inhibitory action of PIASy on BMP-regulated Smad activity was due to direct physical interactions between Smads and PIASy through its RING domain.

The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway. Publishing Authors By Initials

S Imoto,K Sugiyama,T Yamamoto,T Matsuda,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical and biophysical research communication

VOLUME: 319

Page Numbers: 275-82

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 18

MONTH: Jun

YEAR: 2004

The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway. Information

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LANGUAGE: eng

NlmUniqueID: 372516

The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: metabolism

Chemical & Substance for Abstract: The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway. Information

Substance Name: Luciferases

Registry Number: EC 1.13.12.-

Grant and Affiliation Information for The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway.

AFFILIATION: Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-Ku Kita 12 Nishi 6, Sapporo 060-0812, Japan.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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