The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct.

The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct. Research Abstract Details 

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The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct. Abstract Text:

Amy L Cole,Anna Herasimtschuk,Phalguni Gupta,Alan J Waring,Robert I Lehrer,Alexander M Cole,

Retrocyclins are cyclic antimicrobial peptides that exhibit potent activity towards a broad range of primary and laboratory-adapted strains of human immunodeficiency virus type 1 (HIV-1) in vitro. The current study shows that RC-101, an analogue of retrocyclin, prevented HIV-1 infection in an organ-like construct of human cervicovaginal tissue and retained full activity in the presence of vaginal fluid. The peptide remained within the cervicovaginal tissues throughout the 9-day incubation period without altering tissue viability, inducing damage or inducing the release of inflammatory cytokines. Collectively, these data support the potential development of RC-101 as a topical microbicide to prevent HIV-1 infection and transmission.

The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct. Publishing Authors By Initials

AL Cole,A Herasimtschuk,P Gupta,AJ Waring,RI Lehrer,AM Cole,

For similar urogenital system: genitalia: genitalia, female: vagina research abstracts see: urogenital system: genitalia: genitalia, female: vagina research

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The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Immunology

VOLUME: 121

Page Numbers: 140-5

Journal Abbreviation:

ISSN: 0019-2805

DAY: 23

MONTH: 01

YEAR: 2007

The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 374672

The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct. Keywords Mesh Terms:

KEYWORDS: Vagina

MESH TERMS: virology

Chemical & Substance for Abstract: The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct. Information

Substance Name: RC 101

Registry Number: 0

Grant and Affiliation Information for The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct.

AFFILIATION: Department of Molecular Biology & Microbiology, Biomolecular Science Center, Burnett College of Biomedical Sciences at University of Central Florida, Orlando, FL 32816, USA. acole@mail.ucf.edu

Country: England

AGENCY: United States NIAID

GRANT: AI065430

ACRONYM: AI

MEDLINETA: Immunology

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