The responses of extrinsic fibroblasts infiltrating the devitalised patellar tendon to IL-1{beta} are different from those of normal tendon fibroblasts.

The responses of extrinsic fibroblasts infiltrating the devitalised patellar tendon to IL-1{beta} are different from those of normal tendon fibroblasts. Research Abstract Details 

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The responses of extrinsic fibroblasts infiltrating the devitalised patellar tendon to IL-1{beta} are different from those of normal tendon fibroblasts. Abstract Text:

H Tohyama,K Yasuda,H Uchida,J Nishihira,H Tohyama,K Yasuda,H Uchida,J Nishihira,H Tohyama,K Yasuda,H Uchida,J Nishihira,H Tohyama,K Yasuda,H Uchida,J Nishihira,

In order to clarify the role of cytokines in the remodelling of the grafted tendon for ligament reconstruction we compared the responses to interleukin (IL)-1beta, platelet-derived growth factor (PDGF)-BB and transforming growth factor (TGF)-beta1 of extrinsic fibroblasts infiltrating the frozen-thawed patellar tendon in rats with that of the normal tendon fibroblasts, in regard to the gene expression of matrix metalloproteinase (MMP)-13, using Northern blot analysis. We also examined, immunohistologically, the local expression of IL-1beta, PDGF-BB, and TGF-beta1 in fibroblasts infiltrating the frozen-thawed patellar tendon. Northern blot analysis showed that fibroblasts derived from the patellar tendon six weeks after the freeze-thaw procedure in situ showed less response to IL-1beta than normal tendon fibroblasts with respect to MMP-13 mRNA gene expression. The immunohistological findings revealed that IL-1beta was over-expressed in extrinsic fibroblasts which infiltrated the patellar tendon two and six weeks after the freeze-thaw procedure in situ, but neither PDGF-BB nor TGF-beta1 was over-expressed in these extrinsic fibroblasts. Our findings indicated that IL-1beta had a close relationship to matrix remodelling of the grafted tendon for ligament reconstruction, in addition to the commencement of inflammation during the tissue-healing process.

The responses of extrinsic fibroblasts infiltrating the devitalised patellar tendon to IL-1{beta} are different from those of normal tendon fibroblasts. Publishing Authors By Initials

H Tohyama,K Yasuda,H Uchida,J Nishihira,H Tohyama,K Yasuda,H Uchida,J Nishihira,H Tohyama,K Yasuda,H Uchida,J Nishihira,H Tohyama,K Yasuda,H Uchida,J Nishihira,

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The responses of extrinsic fibroblasts infiltrating the devitalised patellar tendon to IL-1{beta} are different from those of normal tendon fibroblasts. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of bone and joint surgery. British vo

VOLUME: 89

Page Numbers: 1261-7

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ISSN: 0301-620X

DAY: 1

MONTH: Sep

YEAR: 2007

The responses of extrinsic fibroblasts infiltrating the devitalised patellar tendon to IL-1{beta} are different from those of normal tendon fibroblasts. Information

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LANGUAGE: eng

NlmUniqueID: 375355

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Grant and Affiliation Information for The responses of extrinsic fibroblasts infiltrating the devitalised patellar tendon to IL-1{beta} are different from those of normal tendon fibroblasts.

AFFILIATION: 1Department of Sports Medicine, Hokkaido University School of Medicine, Kita-15 Nishi-7, Sapporo, 060-8638, Japan.

Country: England

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MEDLINETA: J Bone Joint Surg Br

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