The response of osteocytes to a lipid clearing agent in steroid-treated rabbits.

The response of osteocytes to a lipid clearing agent in steroid-treated rabbits. Research Abstract Details 

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The response of osteocytes to a lipid clearing agent in steroid-treated rabbits. Abstract Text:

H Maruno,T Shimizu,K Kawai,K Hirohata,

We studied the effect of a lipid clearing agent (clinofibrate) on the osteocytes of rabbits treated with corticosteroids. Thirty-one rabbits were divided into four groups: (A) steroid-treated with a normal diet, (B) steroid-treated and one a diet with added clinofibrate, (C) non-steroid-treated, on a diet with clinofibrate; and (D) non-steroid-treated on a normal diet. All the steroid-treated animals demonstrated hyperlipidaemia and fatty degeneration of the liver. Lipid-containing osteocytes were seen in the femoral heads of these animals. However, those which received clinofibrate (group B) had less severe lipidaemia, and less severe degeneration of the liver. In them, only the osteocytes around the haversian canals exhibited lipid inclusions. Clinofibrate appears to modify lipid metabolism, diminishing the steroid induced accumulation of lipids within osteocytes. This effect may protect against steroid-mediated osteonecrosis.

The response of osteocytes to a lipid clearing agent in steroid-treated rabbits. Publishing Authors By Initials

H Maruno,T Shimizu,K Kawai,K Hirohata,

For similar enzymes and coenzymes: enzymes: transferases research abstracts see: enzymes and coenzymes: enzymes: transferases research

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The response of osteocytes to a lipid clearing agent in steroid-treated rabbits. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of bone and joint surgery. British vol

VOLUME: 73

Page Numbers: 911-5

Journal Abbreviation:

ISSN: 0301-620X

DAY: 14

MONTH: Nov

YEAR: 1991

The response of osteocytes to a lipid clearing agent in steroid-treated rabbits. Information

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LANGUAGE: eng

NlmUniqueID: 375355

The response of osteocytes to a lipid clearing agent in steroid-treated rabbits. Keywords Mesh Terms:

KEYWORDS: Transferases

MESH TERMS: blood

Chemical & Substance for Abstract: The response of osteocytes to a lipid clearing agent in steroid-treated rabbits. Information

Substance Name: Transferases

Registry Number: EC 2.-

Grant and Affiliation Information for The response of osteocytes to a lipid clearing agent in steroid-treated rabbits.

AFFILIATION: Department of Orthopaedic Surgery, Kobe University School of Medicine, Japan.

Country: ENGLAND

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MEDLINETA: J Bone Joint Surg Br

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