The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering.

The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering. Abstract Text:

Ramakrishnaiah Siddappa,Hugo Fernandes,Jun Liu,Clemens van Blitterswijk,Jan de Boer,Ramakrishnaiah Siddappa,Hugo Fernandes,Jun Liu,Clemens van Blitterswijk,Jan de Boer,

Bone tissue engineering using human mesenchymal stem cells (hMSCs) is a multidisciplinary field that aims to treat patients with trauma, spinal fusion and large bone defects. Cell-based bone tissue engineering encompasses the isolation of multipotent hMSCs from the bone marrow of the patient, in vitro expansion and seeding onto porous scaffold materials. In vitro pre-differentiation of hMSCs into the osteogenic lineage augments their in vivo bone forming capacity. Differentiation of hMSCs into bone forming osteoblasts is a multi-step process regulated by various molecular signaling pathways, which warrants a thorough understanding of these signaling cues for the efficient use of hMSCs in bone tissue engineering. Recently, there has been a surge of knowledge on the molecular cues regulating osteogenic differentiation but extrapolation to hMSC differentiation is not guaranteed, because of species- and cell-type specificity. In this review, we describe a number of key osteogenic signaling pathways, which directly or indirectly regulate osteogenic differentiation of hMSCs. We will discuss how and to what extent the process is different from that in other cell types with special emphasis on applications in bone tissue engineering.

The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering. Publishing Authors By Initials

R Siddappa,H Fernandes,J Liu,C van Blitterswijk,J de Boer,R Siddappa,H Fernandes,J Liu,C van Blitterswijk,J de Boer,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current stem cell research & therapy

VOLUME: 2

Page Numbers: 209-20

Journal Abbreviation:

ISSN: 1574-888X

DAY: 28

MONTH: Sep

YEAR: 2007

The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101272517

The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering.

AFFILIATION: University of Twente, Institute for BioMedical Technology, Department of Tissue Regeneration, P.O. Box 217, Enschede 7500 AE, The Netherlands. j.deboer@tnw.utwente.nl.

Country: United Arab Emirates

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Curr Stem Cell Res Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering Related Publications

• Autocalibration of spectral-domain optical coherence tomography spectrometers for in vivo quantitative retinal nerve fiber layer birefringence determination.
• Cytokines, chemokines and soluble adhesion molecules in aqueous humor of children with uveitis.
• Depth-resolved measurement of transient structural changes during action potential propagation.
• Do most lymphocytes in humans really reside in the gut?
• Dynamics of CD8+ T cell responses during acute and chronic lymphocytic choriomeningitis virus infection.
• Embryo survival in pseudopregnant and in pregnant but genetically semi-sterile recipients after nonsurgical embryo transfer in the mouse.
• Embryonic development in the pig up to the 64-cell stage, with reference to DNA replication and cell cycle times from the third cleavage division.
• Impact of white-rot fungi on numbers and community composition of bacteria colonizing beech wood from forest soil.
• In vivo thickness and birefringence determination of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomography.
• Incomplete nuclear transformation of human spermatozoa in oligo-astheno-teratospermia: characterization by indirect immunofluorescence of chromatin and thiol status.
• Increased bleeding risk with concurrent use of selective serotonin reuptake inhibitors and coumarins.
• Invivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography.
• Kinetics of first polar body extrusion and the effect of time of stripping of the cumulus and time of insemination on developmental competence of bovine oocytes.
• Left main coronary artery stenosis undetected by 64-slice computed tomography: a word of caution.
• Motile human normozoospermic and oligozoospermic semen samples show a difference in double-strand DNA break incidence.
• Public farms: hygiene and zoonotic agents.
• Selective expansion of influenza a virus specific T cells in symptomatic human carotid artery atherosclerotic plaques.
• Self-assembled-monolayer formation of long alkanedithiols in molecular junctions.
• Sex determination in the hymenoptera.
• Should more hospitals in the Netherlands provide PCI without on-site cardiac surgery?
• Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomography.
• Spectral shaping for non-Gaussian source spectra in optical coherence tomography.
• Spectral-domain optical coherence phase and multiphoton microscopy.
• Spectral-domain optical coherence reflectometric sensor for highly sensitive molecular detection.
• The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering.
• The trans-envelope Tol-Pal complex is part of the cell division machinery and required for proper outer-membrane invagination during cell constriction in E. coli.
• Ultra-high speed and ultra-high resolution spectral-domain optical coherence tomography and optical Doppler tomography in ophthalmology.
• Use of trastuzumab for metastatic breast cancer in Australia: inaccurate results and alternative interpretation of findings.
• [Not Available.]
• [Not Available.]