The renin-angiotensin system and the pathogenesis of vascular disease in malignant hypertension.

The renin-angiotensin system and the pathogenesis of vascular disease in malignant hypertension. Research Abstract Details 

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The renin-angiotensin system and the pathogenesis of vascular disease in malignant hypertension. Abstract Text:

J Geise,

1. The syndrome of malignant hypertension in man and animals has three fundamental components: high blood pressure, activation of the renin-angiotensin system and the rapid development of necrotizing arteriolar disease. 2. The high blood pressure can be associated with different conformations of the arteriolar microcirculation. The emergence of an arteriolar reaction pattern characterized by the formation of focal dilatations, with intervening constricted segments, is of fundamental pathophysiological importance. 3. Activation of the renin system is reflected in an increased renin secretion rate from the kidneys and an increased rate of angiotensin II generation in the pulmonary vascular bed. 4. The crucial pathogenetic process, leading eventually to severe arteriolar wall damage, is a penetration of plasmatic macromolecules into the wall of distended arteriolar segments, as observed in states of severe experimental hypertension. 5. Renin can induce vascular disease, but hypersecretion of renin is not a necessary condition for the development of hypertensive arteriolar necrosis.

The renin-angiotensin system and the pathogenesis of vascular disease in malignant hypertension. Publishing Authors By Initials

J Geise,

For similar cardiovascular diseases: vascular diseases research abstracts see: cardiovascular diseases: vascular diseases research

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The renin-angiotensin system and the pathogenesis of vascular disease in malignant hypertension. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical science and molecular medicine. Supplemen

VOLUME: 3

Page Numbers: 19s-21s

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ISSN: 0144-4107

DAY: 12

MONTH: Dec

YEAR: 1976

The renin-angiotensin system and the pathogenesis of vascular disease in malignant hypertension. Information

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LANGUAGE: eng

NlmUniqueID: 7907311

The renin-angiotensin system and the pathogenesis of vascular disease in malignant hypertension. Keywords Mesh Terms:

KEYWORDS: Vascular Diseases

MESH TERMS: etiology

Chemical & Substance for Abstract: The renin-angiotensin system and the pathogenesis of vascular disease in malignant hypertension. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for The renin-angiotensin system and the pathogenesis of vascular disease in malignant hypertension.

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Country: ENGLAND

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MEDLINETA: Clin Sci Mol Med Suppl

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