The relationship of pronuclear stage morphology and chromosome status at cleavage stage.

The relationship of pronuclear stage morphology and chromosome status at cleavage stage. Research Abstract Details 

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The relationship of pronuclear stage morphology and chromosome status at cleavage stage. Abstract Text:

PURPOSE: Infertile couples undergoing in vitro fertilization-embryo transfer (IVF-ET) program were included to study the relationship of pronuclear stage morphology and chromosome status at cleavage stage. METHODS: Eighteen to twenty-one hours after fertilization, zygotes were checked for pronuclear morphology with modified Scott Z-score system. After embryo transfer on day 3, arrested or non-transferred 2 PN embryos were spread for fluorescence in situ hybridization (FISH) staining of probes to chromosomes 18, X and Y. RESULTS: Ninety-eight embryos were successfully fixed and stained. The chromosome status were recorded in each 2 PN score group: 7 (54%) of 13 embryos in Z2 group, 14 (35%) of 40 in Z3 group and 10 (36%) of 28 in Z4 group being normal diploid. Z1 group has 12 (71%) of 17 embryos being normal diploid, which is significantly more than Z3 (p = 0.020) and Z4 group (p = 0.033). CONCLUSION: Our results demonstrated a high probability to get normal diploid embryos if good morphology at pronuclear stage was used as selection criteria, especially for Z1 score embryos.

The relationship of pronuclear stage morphology and chromosome status at cleavage stage. Publishing Authors By Initials

For similar urogenital system: genitalia: germ cells: ovum: zygote research abstracts see: urogenital system: genitalia: germ cells: ovum: zygote research

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The relationship of pronuclear stage morphology and chromosome status at cleavage stage. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of assisted reproduction and genetics

VOLUME: 20

Page Numbers: 413-20

Journal Abbreviation: J. Assist. Reprod. Genet.

ISSN: 1058-0468

DAY: 17

MONTH: Oct

YEAR: 2003

The relationship of pronuclear stage morphology and chromosome status at cleavage stage. Information

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LANGUAGE: eng

NlmUniqueID: 9206495

The relationship of pronuclear stage morphology and chromosome status at cleavage stage. Keywords Mesh Terms:

KEYWORDS: Zygote

MESH TERMS: ultrastructure

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Grant and Affiliation Information for The relationship of pronuclear stage morphology and chromosome status at cleavage stage.

AFFILIATION: Department of Obstetrics and Gynecology, Lin-Kou Medical Center, Chang Gung Memorial Hospital and Medical College, 5, Fu-Hsing Street, Kwei-Shan, Tao-Yuan 333, Taiwan. ckchen@cgmh.org.tw

Country: United States

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MEDLINETA: J Assist Reprod Genet

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