[The relationship of low density lipoprotein receptor gene polymorphism and hyperlipidemia]

[The relationship of low density lipoprotein receptor gene polymorphism and hyperlipidemia] Research Abstract Details 

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[The relationship of low density lipoprotein receptor gene polymorphism and hyperlipidemia] Abstract Text:

A Liu,S Zhan,L Li,

OBJECTIVE: To study the relationship of low density lipoprotein receptor gene polymorphism and hyperlipidemia in the population with essential hypertension. METHODS: People with different lipid levels including 107 hyperlipidemia, 104 at margin level and 108 normal were recruited in the study. Their polymorphisms of LDL-R gene were analyzed using PCR-RFLP. RESULTS: There were three kinds of genotype: (+/+), (+/-), (-/-). In male, the frequencies of the (+/-) in three study groups were shown as follows: 41.18% in hyperlipidemia, 46.15% in margin level, 19.05% in normal lipid. The frequency of (+) allele was significantly higher in hyperlipidemia than that in normal lipid (24.51%, 25.00% and 11.11%, respectively). In women, the differences were not statistically significant. The nonconditional univariate and multivariate logistic regression analysis demonstrated that (+) allele of Ava II polymorphism of LDL-R was a genetic marker of male's hypercholesterolemia. CONCLUSIONS: The frequency of (+/-) hyperlipidemia in males was higher than that in normal lipid group and the (+) allele in male hyperlipidemia was significantly more frequent seen than that in normal lipid group. These results suggested that polymorphisms of LDL-Rgene might play an independent role of risk factor for hyperlipidemia.

[The relationship of low density lipoprotein receptor gene polymorphism and hyperlipidemia] Publishing Authors By Initials

A Liu,S Zhan,L Li,

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[The relationship of low density lipoprotein receptor gene polymorphism and hyperlipidemia] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxi

VOLUME: 22

Page Numbers: 30-3

Journal Abbreviation: Zhonghua Liu Xing Bing Xue Za

ISSN: 0254-6450

DAY: 25

MONTH: Feb

YEAR: 2001

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LANGUAGE: chi

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AFFILIATION: Department of Epidemiology, Beijing Medical University, China.

Country: China

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MEDLINETA: Zhonghua Liu Xing Bing Xue Za

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