The relationship of endothelin-1 and inducible nitric oxide synthase at several stages of the anastomotic healing process.

The relationship of endothelin-1 and inducible nitric oxide synthase at several stages of the anastomotic healing process. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The relationship of endothelin-1 and inducible nitric oxide synthase at several stages of the anastomotic healing process. Abstract Text:

AIM: The aim of this study was to investigate the interaction between the endothelin-1 (ET-1) and inducible NO synthase (iNOS) in anastomotic healing. METHODS: The expression of ET-1 and iNOS were investigated by immunohistochemistry in a rat end-to-end arterial anastomotic model. The aorta of 50 mail Wistar rats was exposed, then transversely divided and re-anastomosed. The animals were sacrificed immediately after the operation (group A, control group), after 24 h (group B), on 7th postoperative day (group C), on 30th day (group D) and at 6 months (group E). Intima and media thickness and their ratio of the anastomotic segments in each group were calculated from computer digitized images of the individual sections. ET-1 and iNOS expression were measured on a semiquantitative scale ranging from 0 to 3. RESULTS: ET-1 was expressed from endothelial and smooth muscle cells (SMCs), while iNOs was expressed from SMCs and inflammatory cells. An intense expression of ET-1 was demonstrated mainly at 1 week and to a lesser degree at 1 month. Yet, at 6 months this expression was significantly weakened (P<0.001). In contrast, an intense iNOS expression was identified at 24 h, substantially regressing at statistical significant lower levels after 1 week (P<0.001). Bivariate correlation test showed a positive correlation between ET-1 and iNOS expression. CONCLUSION: ET-1 appears to play an important role in intimal thickening during anastomotic healing, especially in the late period of the process. Although there is a positive correlation between ET-1 and iNOS production, the activity of the latter is relatively limited after the first postanastomosis week.

The relationship of endothelin-1 and inducible nitric oxide synthase at several stages of the anastomotic healing process. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The relationship of endothelin-1 and inducible nitric oxide synthase at several stages of the anastomotic healing process. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International angiology : a journal of the Interna

VOLUME: 27

Page Numbers: 302-6

Journal Abbreviation:

ISSN: 0392-9590

DAY: 4

MONTH: Aug

YEAR: 2008

The relationship of endothelin-1 and inducible nitric oxide synthase at several stages of the anastomotic healing process. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8402693

The relationship of endothelin-1 and inducible nitric oxide synthase at several stages of the anastomotic healing process. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The relationship of endothelin-1 and inducible nitric oxide synthase at several stages of the anastomotic healing process. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The relationship of endothelin-1 and inducible nitric oxide synthase at several stages of the anastomotic healing process.

AFFILIATION: Division of Vascular Surgery, 1st Department of Surgery, Medical School, University of Athens, Athens, Greece sgeorg@med.uoa.gr.

Country: Italy

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Int Angiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The relationship of endothelin-1 and inducible nitric oxide synthase at several stages of the anastomotic healing process Related Publications

• A hybrid approach using a composite endovascular and open graft procedure for a symptomatic common femoral aneurysm extending well above the inguinal ligament.
• Alterations of hemostasis after laparoscopic and open surgery.
• Can the diameter of endoluminal shunt influence the risk of hyperperfusion syndrome after carotid endarterectomy?
• Comparison of safety and efficacy of ultrasonic and bipolar thermal energy: an experimental study.
• Emergency stenting of a ruptured infected anastomotic femoral pseudoaneurysm.
• Endovascular repair of a type III thoracoabdominal aortic aneurysm in a patient with occlusion of visceral arteries.
• Epstein-Barr virus - associated adenocarcinoma of the stomach: a rare entity with distinct characteristics.
• High-Sensitivity CRP Is Correlated With Neurologic Symptoms and Plaque Instability in Patients With Severe Stenosis of the Carotid Bifurcation.
• Primary stenting for aortic lesions: From single stenoses to total aortoiliac occlusions.
• The relationship of endothelin-1 and inducible nitric oxide synthase at several stages of the anastomotic healing process.
• The use of Speckle Reduction Imaging (SRI) Ultrasound in the characterization of carotid artery plaques.