[The relationship between hemoglobin adducts of trinitrotoluene and exposed level]

[The relationship between hemoglobin adducts of trinitrotoluene and exposed level] Research Abstract Details 

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[The relationship between hemoglobin adducts of trinitrotoluene and exposed level] Abstract Text:

Wenjia Song,Yawen Wang,Huifang Yan,Shuguang Leng,Yeping Gu,Yuying Liu,Yuxin Zheng,

OBJECTIVE: To explore the biomarkers for monitoring trinitrotoluene (TNT) exposure, the relationship between TNT hemoglobin adducts and TNT exposed level. METHOD: Hemoglobin adducts (4A-Hb and 2A-Hb) were determined by GC-MS in 25 TNT exposed workers. TNT exposed level was evaluated by determining skin contaminated and inhaled TNT levels. The correlation between hemoglobin adducts level and TNT exposed level was analyzed. RESULTS: There was a correlation between total TNT exposure level, especially skin exposure level, and 4A-Hb or 2A-Hb content. No significant difference was found between the slopes and intercepts of lin ear equation of (4A-Hb) vs TNT exposed level and linear equation of (4A-Hb +2A-Hb) vs TNT exposed level (P > 0.05). CONCLUSION: Skin contamination is the major role of TNT exposure. TNT exposed level can be evaluated by determining the content of both 4A-Hb and 2A-Hb, and 4A-Hb is more suitable for monitoring TNT exposure.

[The relationship between hemoglobin adducts of trinitrotoluene and exposed level] Publishing Authors By Initials

W Song,Y Wang,H Yan,S Leng,Y Gu,Y Liu,Y Zheng,

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[The relationship between hemoglobin adducts of trinitrotoluene and exposed level] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Z

VOLUME: 20

Page Numbers: 189-91

Journal Abbreviation: Zhonghua Lao Dong Wei Sheng Zh

ISSN: 1001-9391

DAY: 25

MONTH: Jun

YEAR: 2002

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LANGUAGE: chi

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AFFILIATION: Institute of Occupational Health, Chinese Academy of Preventive Medicine, Beijing 100050, China.

Country: China

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MEDLINETA: Zhonghua Lao Dong Wei Sheng Zh

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