[The relationship between haplotypes of multilocus markers and ankylosing spondylitis]

[The relationship between haplotypes of multilocus markers and ankylosing spondylitis] Research Abstract Details 

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[The relationship between haplotypes of multilocus markers and ankylosing spondylitis] Abstract Text:

Ming-min Gu,Wen-tao Yuan,Jue-qin Yang,Jing Zhang,Xiao-yan Xiong,Fang-juan Yao,Zhen-yu Lu,Zhu-gang Wang,Wei Huang,Li-an Fan,

OBJECTIVE: To investigate the relationship between haplotypes of multilocus markers and ankylosing spondylitis (AS). METHODS: Five families with AS were recruited from Shanghai area. Eleven microsatellite markers around D6S276 were analyzed by Linkage package and by Cyrillic package. RESULTS: Fine linkage analysis showed the significant Lod score values with D6S276 was 3.8821, Lod score values with D6S1691 and D6S1618 near D6S276 were larger than 1.5. The crossover value in 5 pedigrees was 14%. The haplotype analysis showed that the regions between D6S1691 and D6S1618 were associated with AS. CONCLUSION: The regions of D6S1691-D6S276-D6S1618 may harbor a susceptible gene of AS. The specific haplotypes of different pedigrees may play an important role in the presymptomatic diagnosis for AS.

[The relationship between haplotypes of multilocus markers and ankylosing spondylitis] Publishing Authors By Initials

MM Gu,WT Yuan,JQ Yang,J Zhang,XY Xiong,FJ Yao,ZY Lu,ZG Wang,W Huang,LA Fan,

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[The relationship between haplotypes of multilocus markers and ankylosing spondylitis] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yix

VOLUME: 21

Page Numbers: 312-5

Journal Abbreviation: Zhonghua Yi Xue Yi Chuan Xue Z

ISSN: 1003-9406

DAY: 9

MONTH: Aug

YEAR: 2004

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LANGUAGE: chi

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AFFILIATION: Department of Medical Genetics,Shanghai Second Medical University, Shanghai, 200025 PR China.

Country: China

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MEDLINETA: Zhonghua Yi Xue Yi Chuan Xue Z

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