The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan.

The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan. Abstract Text:

Molly E Zimmerman,Adam M Brickman,Robert H Paul,Stuart M Grieve,David F Tate,John Gunstad,Ronald A Cohen,Mark S Aloia,Leanne M Williams,C Richard Clark,Thomas J Whitford,Evian Gordon,

OBJECTIVE: Age-associated decline in gray matter brain volume and cognitive function in healthy adults has been reported in the literature. The goal of the current study is to examine the relationship between age-related changes in regional gray matter volumes and cognitive function in a large, cross-sectional sample of healthy adults across the lifespan. METHODS: Magnetic resonance imaging and cognitive assessment were conducted on 148 adults aged 21-76 years. Multiple regression analyses examining the effect of age were performed on magnetic resonance image-derived gray matter brain volumes and standardized cognitive summary scores of attention and executive function. Regression was also performed to test the effect of age, gray matter volumes, and their interaction on the prediction of cognitive performance. RESULTS: Age significantly predicted performance on tests of attention (F [1, 146]=50.97, p <0.01, R2=0.26) and executive function (F [1, 146]=126.19, p <0.01, R2=0.46) and gray matter volumes for frontal subregions (lateral, medial, orbital), hippocampus, amygdala, and putamen (F [2, 145]=45.34-23.96, p <0.01-0.02). Lateral frontal (beta=-1.53, t=-2.16, df=131, p <0.03) and orbital frontal (beta=1.24, t=2.08, df=131, p <0.04) regions significantly predicted performance on tests of attention. Lateral frontal (beta=-1.69, t=-2.83, df=131, p <0.01) and the interaction between age and lateral frontal volume (beta=3.76, t=2.49, df=131, p <0.02) significantly predicted executive function. CONCLUSIONS: The findings confirm age-associated decline in cognitive function and gray matter volumes, particularly in anterior cortical brain regions. Furthermore, the association between lateral frontal gray matter volume and the ability to successfully plan, organize, and execute strategies varies as a function of age across the healthy adult lifespan.

The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan. Publishing Authors By Initials

ME Zimmerman,AM Brickman,RH Paul,SM Grieve,DF Tate,J Gunstad,RA Cohen,MS Aloia,LM Williams,CR Clark,TJ Whitford,E Gordon,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of geriatric psychiatry : off

VOLUME: 14

Page Numbers: 823-33

Journal Abbreviation:

ISSN: 1064-7481

DAY: 3

MONTH: Oct

YEAR: 2006

The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9309609

The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan.

AFFILIATION: Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island, USA. mzimmerm@aecom.yu.edu

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Am J Geriatr Psychiatry

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan Related Publications

• Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid.
• Are molecular haplotypes worth the time and expense? A cost-effective method for applying molecular haplotypes.
• Brood production and lineage discrimination in the red harvester ant (Pogonomyrmex barbatus).
• Canonical TTAGG-repeat telomeres and telomerase in the honey bee, Apis mellifera.
• Cholesteatoma, cerebrospinal fluid leakage, and chronic otitis media.
• Developing models for patient flow and daily surge capacity research.
• Effect of recovery method on yield of bovine oocytes per ovary and their developmental competence after maturation, fertilization and culture in vitro.
• Effects of constraint-induced therapy on hand function in children with hemiplegic cerebral palsy.
• Effects of nutrition, puberty, and gender on bone ultrasound measurements in adolescents and young adults.
• Extranuclear sequestration of phospho-Jun N-terminal kinase and distorted villi produced by activated Rac1 in the intestinal epithelium of chimeric mice.
• Functional genomic and metabolic studies of the adaptations of a prominent adult human gut symbiont, Bacteroides thetaiotaomicron, to the suckling period.
• Genetic caste determination in harvester ants: possible origin and maintenance by cyto-nuclear epistasis.
• Genomic and metabolic studies of the impact of probiotics on a model gut symbiont and host.
• Impaired anticipatory control of fingertip forces in patients with a pure motor or sensorimotor lacunar syndrome.
• Interruption-similarity effects during discourse processing.
• Luminance-contrast mechanisms in humans: visual evoked potentials and a nonlinear model.
• Methanol-water mixtures: a microsolvation study using the effective fragment potential method.
• Micromanipulation of sheep morulae to produce monozygotic twins.
• Radioimmunoassay and enzymeimmunoassay of plasma progesterone as monitors of progesterone sponge treatment in ewes.
• Report on the vitamin D status of adult and pediatric patients with inflammatory bowel disease and its significance for bone health and disease.
• Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women.
• Selective attention during scene perception: evidence from negative priming.
• Selective reduction of peptide isothiazolidin-3-ones.
• Sharp recanalization of a short esophageal occluding stricture in a patient with epidermolysis bullosa.
• Structural complexity of chemical recognition cues affects the perception of group membership in the ants Linephithema humile and Aphaenogaster cockerelli.
• Superovulation and oocyte recovery in the ewe.
• Superovulation in the cow using PMSG or HAP.
• Superovulation in the ewe using HAP.
• The relationship between frontal gray matter volume and cognition varies across the healthy adult lifespan.
• Virally mediated knock-down of NR2 subunits ipsilateral to the deprived eye blocks ocular dominance plasticity.