The relationship between bone-loss of steroid-induced osteonecrosis and local expression of OPG/OCIF.

The relationship between bone-loss of steroid-induced osteonecrosis and local expression of OPG/OCIF. Research Abstract Details 

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The relationship between bone-loss of steroid-induced osteonecrosis and local expression of OPG/OCIF. Abstract Text:

Yan Wang,Zhiyong Chi,Gang Han,

OBJECTIVE: To probe the relationship between the osteoprotegerin/osteoclastogenesis inhibitory factor (OPG/OCIF) expression of bone and the relative bone-loss. METHODS: Steroid-induced osteonecrosis-model was reproduced in thirty-one new Zealand hares, and 24 ones were alive 3 days after administration of endotoxin and methylprednisolone. The alive creatures were divided into control group and trial groups randomly. After the creatures being executed, bone-density measurement of the femurs, HE staining, Ca(+ +) staining and OPG/OCIF immunohistochemistry staining were performed, followed by image processing and statistical analysis. RESULTS: In the early period of steroid-induced osteonecrosis, the local OPG/OCIF expression significantly decreased, with a large number of osteoclasts in the local medulla, followed by a progressively bone-loss. CONCLUSION: Corticosteroid could inhibit OPG/OCIF expression in the bone, increase the activity and differentiation of osteoclast relatively, and worsen bone-loss in steroid-induced osteonecrosis.

The relationship between bone-loss of steroid-induced osteonecrosis and local expression of OPG/OCIF. Publishing Authors By Initials

Y Wang,Z Chi,G Han,

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The relationship between bone-loss of steroid-induced osteonecrosis and local expression of OPG/OCIF. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of

VOLUME: 36

Page Numbers: 534-7

Journal Abbreviation: Zhonghua Yu Fang Yi Xue Za Zhi

ISSN: 0253-9624

DAY: 4

MONTH: Dec

YEAR: 2002

The relationship between bone-loss of steroid-induced osteonecrosis and local expression of OPG/OCIF. Information

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LANGUAGE: eng

NlmUniqueID: 7904962

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Grant and Affiliation Information for The relationship between bone-loss of steroid-induced osteonecrosis and local expression of OPG/OCIF.

AFFILIATION: Department of Orthopedic, General Hospital of People's Liberation Army, Beijing 100853, China.

Country: China

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MEDLINETA: Zhonghua Yu Fang Yi Xue Za Zhi

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