[The regulating effect of antisense-S-Oligo on TYR gene expression and melanin production of melanocytes]

[The regulating effect of antisense-S-Oligo on TYR gene expression and melanin production of melanocytes] Research Abstract Details 

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[The regulating effect of antisense-S-Oligo on TYR gene expression and melanin production of melanocytes] Abstract Text:

Yu-guang Zhang,Qiong-hua Hu,Xun-zhang Wang,Zuo-liang Qi,Xiao-xi Lin,Jian-lin Fang,Chuan-chang Dai,

OBJECTIVE: Despite the causes for melanin increase, the increased gene expression of TYR is a common pathological process. Based on this viewpoint, antisense-S-Oligo of TYR was designed and synthesized to regulate synthesis of melanin in order to explore the treatment for skin pigmentation. METHODS: The cultured melanocytes were divided into 3 groups. The group 1 was treated with endothelin, group 2 treated with ultraviolet ray and group 3 was used as the control. In each group, the 5' antisense-S-Oligo, the 3' antisense-S-Oligo, the mixed antisense-S-Oligo of TYR or Dotap only was added. The melanin content and TYR gene expressions were examined. RESULTS: The 5' antisense-S-Oligo, the 3' antisense-S-Oligo and the mixed antisense-S-Oligo significantly inhibited the increase of melanin content and TYR gene expression, which were caused by endothelin or ultraviolet ray treatment. Of the three treatments, the 3' antisense-S-Oligo showed the strongest effect. CONCLUSION: Antisense-S-Oligo has significant regulating effects on TYR gene expression and melanin content. The 3' antisense-S-Oligo is more effective than the 5' antisense-S-Oligo.

[The regulating effect of antisense-S-Oligo on TYR gene expression and melanin production of melanocytes] Publishing Authors By Initials

YG Zhang,QH Hu,XZ Wang,ZL Qi,XX Lin,JL Fang,CC Dai,

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[The regulating effect of antisense-S-Oligo on TYR gene expression and melanin production of melanocytes] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua zheng xing wai ke za zhi = Zhonghua zheng

VOLUME: 19

Page Numbers: 285-7

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ISSN: 1009-4598

DAY: 21

MONTH: Jul

YEAR: 2003

[The regulating effect of antisense-S-Oligo on TYR gene expression and melanin production of melanocytes] Information

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LANGUAGE: chi

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AFFILIATION: Department of Plastic and Reconstructive Surgery of Shanghai the Ninth People's Hospital, Shanghai 200011, China.

Country: China

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MEDLINETA: Zhonghua Zheng Xing Wai Ke Za

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