The redox-switch domain of Hsp33 functions as dual stress sensor.

The redox-switch domain of Hsp33 functions as dual stress sensor. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The redox-switch domain of Hsp33 functions as dual stress sensor. Abstract Text:

Marianne Ilbert,Janina Horst,Sebastian Ahrens,Jeannette Winter,Paul C F Graf,Hauke Lilie,Ursula Jakob,

The redox-regulated chaperone Hsp33 is specifically activated upon exposure of cells to peroxide stress at elevated temperatures. Here we show that Hsp33 harbors two interdependent stress-sensing regions located in the C-terminal redox-switch domain of Hsp33: a zinc center sensing peroxide stress conditions and an adjacent linker region responding to unfolding conditions. Neither of these sensors works sufficiently in the absence of the other, making the simultaneous presence of both stress conditions a necessary requirement for Hsp33's full activation. Upon activation, Hsp33's redox-switch domain adopts a natively unfolded conformation, thereby exposing hydrophobic surfaces in its N-terminal substrate-binding domain. The specific activation of Hsp33 by the oxidative unfolding of its redox-switch domain makes this chaperone optimally suited to quickly respond to oxidative stress conditions that lead to protein unfolding.

The redox-switch domain of Hsp33 functions as dual stress sensor. Publishing Authors By Initials

M Ilbert,J Horst,S Ahrens,J Winter,PC Graf,H Lilie,U Jakob,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

The redox-switch domain of Hsp33 functions as dual stress sensor. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature structural & molecular biology

VOLUME: 14

Page Numbers: 556-63

Journal Abbreviation: Nat. Struct. Mol. Biol.

ISSN: 1545-9993

DAY: 21

MONTH: 05

YEAR: 2007

The redox-switch domain of Hsp33 functions as dual stress sensor. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101186374

The redox-switch domain of Hsp33 functions as dual stress sensor. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: The redox-switch domain of Hsp33 functions as dual stress sensor. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for The redox-switch domain of Hsp33 functions as dual stress sensor.

AFFILIATION: Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 N-University, Ann Arbor, Michigan 48109-1048, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM065318

ACRONYM: GM

MEDLINETA: Nat Struct Mol Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The redox-switch domain of Hsp33 functions as dual stress sensor Related Publications

• Assessment of pulmonary perfusion in a single shot using SEEPAGE.
• Fractures associated with patellar ligament grafts in cruciate ligament surgery.
• Lipid-lowering effect of preoperative statin therapy on postoperative major adverse cardiac events after coronary artery bypass surgery.
• Lung MRI using an MR-compatible active breathing control (MR-ABC).
• Magnetic resonance imaging in coronary artery bypass surgery--improvement of global and segmental function in patients with severely compromized left ventricular function.
• Muscular strength after rupture of the long head of the biceps.
• Nitrosative stress treatment of E. coli targets distinct set of thiol-containing proteins.
• Posterior instability of the knee near extension. A clinical and stress radiographic analysis of acute injuries of the posterior cruciate ligament.
• Results of surgical treatment of multifragmented fractures of the humeral head.
• The immediate and sustained effects of volume challenge on regional blood flows in pigs.
• The non operative treatment of isolated complete tears of the medial collateral ligament of the knee. A prospective study.
• The redox-switch domain of Hsp33 functions as dual stress sensor.
• Treatment of cartilage defects of the talus by autologous osteochondral grafts.
• [A new highly active anticoagulant with prolonged effect (marcoumar).]
• [Clinical examination of hip joint (author's transl)]
• [Distraction of unstable distal comminuted radius fractures with an external fixation device: a new way of treatment]
• [Fractures in the knee joint region: errors, hazards, complications]
• [Frostbite in the high mountains]
• [Indication for surgical treatment of acute collateral ligament injury at the knee joint]
• [Joint sprains in sport]
• [Joint-cartilage lesions (author's transl)]
• [Knee injuries in general practice]
• [Metabolic bone diseases]
• [On the cause of the anterolateral instability of the knee joint. A study on 20 cadaver knee joints with special regard to the tractus iliotibialis (author's transl)]
• [Orthopedic examination techniques of the knee joint--basis for diagnosis and indications]
• [Rehabilitation of hemiplegia]
• [Shaving of the cartilage: how much is healthy?]
• [The differential diagnosis of hip disease in childhood (author's transl)]
• [The radioisotopes; an introductive description of their biological and medical use.]
• [The value of corrective osteotomies--indications, technique, results]