The reactive metabolite target protein database (TPDB)--a web-accessible resource.

The reactive metabolite target protein database (TPDB)--a web-accessible resource. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The reactive metabolite target protein database (TPDB)--a web-accessible resource. Abstract Text:

Robert P Hanzlik,Yakov M Koen,Bhargav Theertham,Yinghua Dong,Jianwen Fang,

BACKGROUND: The toxic effects of many simple organic compounds stem from their biotransformation to chemically reactive metabolites which bind covalently to cellular proteins. To understand the mechanisms of cytotoxic responses it may be important to know which proteins become adducted and whether some may be common targets of multiple toxins. The literature of this field is widely scattered but expanding rapidly, suggesting the need for a comprehensive, searchable database of reactive metabolite target proteins. DESCRIPTION: The Reactive Metabolite Target Protein Database (TPDB) is a comprehensive, curated, searchable, documented compilation of publicly available information on the protein targets of reactive metabolites of 18 well-studied chemicals and drugs of known toxicity. TPDB software enables i) string searches for author names and proteins names/synonyms, ii) more complex searches by selecting chemical compound, animal species, target tissue and protein names/synonyms from pull-down menus, and iii) commonality searches over multiple chemicals. Tabulated search results provide information, references and links to other databases. CONCLUSION: The TPDB is a unique on-line compilation of information on the covalent modification of cellular proteins by reactive metabolites of chemicals and drugs. Its comprehensiveness and searchability should facilitate the elucidation of mechanisms of reactive metabolite toxicity. The database is freely available at http://tpdb.medchem.ku.edu/tpdb.html.

The reactive metabolite target protein database (TPDB)--a web-accessible resource. Publishing Authors By Initials

RP Hanzlik,YM Koen,B Theertham,Y Dong,J Fang,

For similar information science: computing methodologies: software: user-computer interface research abstracts see: information science: computing methodologies: software: user-computer interface research

PUBMED ID PMID:

MEDLINE DATE:

The reactive metabolite target protein database (TPDB)--a web-accessible resource. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: BMC bioinformatics

VOLUME: 8

Page Numbers: 95

Journal Abbreviation: BMC Bioinformatics

ISSN: 1471-2105

DAY: 16

MONTH: 03

YEAR: 2007

The reactive metabolite target protein database (TPDB)--a web-accessible resource. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100965194

The reactive metabolite target protein database (TPDB)--a web-accessible resource. Keywords Mesh Terms:

KEYWORDS: User-Computer Interface

MESH TERMS: metabolism

Chemical & Substance for Abstract: The reactive metabolite target protein database (TPDB)--a web-accessible resource. Information

Substance Name: Proteins

Registry Number: 0

Grant and Affiliation Information for The reactive metabolite target protein database (TPDB)--a web-accessible resource.

AFFILIATION: Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA. rhanzlik@ku.edu

Country: England

AGENCY: United States NCRR

GRANT: P20 RR016475

ACRONYM: RR

MEDLINETA: BMC Bioinformatics

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The reactive metabolite target protein database TPDB--a web-accessible resource Related Publications

• Alterations of MUC1 and MUC3 expression in gastric carcinoma: relevance to patient clinicopathological features.
• Population structure and gene flow among wild populations of the black muntjac (Muntiacus crinifrons) based on mitochondrial DNA control region sequences.
• Transcriptional mRNA of bone morphogenetic proteins 2, 3, 4, and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors.
• [A clinical analysis of hepatolenticular degeneration in 42 patients]
• [A clinical study on delayed encephalopathy after carbon monoxide poisoning]
• [Analysis of C5 fractions and carbonyl compounds by capillary gas chromatography]
• [Clinical application of peroneal muscles tendon transposition in repair of Achilles tendon rupture]
• [Clinical significance of early diagnose and treatment of subclinical renal allograft rejection]
• [Clinical study on spinal cord injury without radiologic abnormality in children]
• [Comparison of various kinds of internal fixations in unstable intertrochanteric femoral fracture]
• [Determination of gamma-aminobutyric acid and glutamic acid in human cerebrospinal fluid by high performance liquid chromatography]
• [Distribution of neuropeptide Y-like and beta-endorphin-like immunoreactivity in the nervous system and Hatschek's pit of amphioxus, Branchiostoma belcheri]
• [Effect of Twin-block appliance in the treatment of Class II and division I malocclusion: a cephalometric study in 12 patients]
• [Investigation of an outbreak of acute diarrhea caused by human calicivirus]
• [Mechanism of oral absorption of panaxnotoginseng saponins]
• [Nine cases of laparoscopic retroperitoneal lymph node dissection]
• [Progress in application of surface enhanced Raman scattering spectrum technique]
• [Relationship between anatomy of knee colateral ligament and geometry of posterior femoral condylar articular surface]
• [Research on continuous measurement of blood pressure via characteristic parameters of pulse wave]
• [Studies on polysaccharide peptide with high performance gel permeation chromatography]
• [Studies on sequential injection spectrophotometric system using a reflective flow cell for process analysis]
• [Study of the photoluminescence spectra of laser dye impregnated in porous silicon]
• [Study on interaction of adriamycin and DNA with a resonance light scattering technique and its DNA analytical application]
• [Study on the NIR-Raman spectra and NIR-SERS spectra of amsacrine]
• [Systemic lupus erythematosus with Evan's syndrome as primary symptom in a case]
• [Temperature distribution measurement of high energetic monopropellant by spectroscopic diagnostic technology]
• [The changes in serum antibody level after immunization with HFRS vaccine]
• [The design of the external defibrillator using the truncated exponential biphasic waveform]
• [The historical condition in the spread of Sanqi (Panax notoginseng) in the Ming Dynasty]
• [The impact of expansion of sirolimus eluting stent on intimal hyperplasia: an intravascular ultrasound study]