The rapid onset of functional tolerance to ethanol--role of different neurotransmitters and synaptosomal membrane lipids.

The rapid onset of functional tolerance to ethanol--role of different neurotransmitters and synaptosomal membrane lipids. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The rapid onset of functional tolerance to ethanol--role of different neurotransmitters and synaptosomal membrane lipids. Abstract Text:

J M Littleton,G R John,P A Jones,S J Grieve,

The rapid onset of functional tolerance to ethanol was studied in young adult mice of the TO Swiss and C57 Black strains. Drugs known to alter the metabolism of catecholamines and 5-hydroxytryptamine in mouse brain were without effect on the development of tolerance to ethanol. Amino-oxyacetic acid, which potentiates gamma-aminobutyric acid (GABA), slightly inhibited the development of tolerance, whereas the GABA antagonist, picrotoxin, produced a small increase in tolerance. The effects of treatments which altered synaptosomal membrane lipid composition were also investigated. Prolonged treatment of mice with diazacholesterol, an inhibitor of cholesterol synthesis, reduced the cholesterol content of synaptosomal membranes and, while not altering the initial sensitivity of mice to ethanol, prevented the subsequent development of tolerance. In contrast, feeding mice a diet rich in saturated fats throughout their lives reduced the unsaturated fat content of synaptosomal membranes and appeared to reduce the initial sensitivity of mice to ethanol. These results are consistent with our previous hypothesis that a reduction in unsaturation of synaptosomal membrane lipids underlies the rapid onset of ethanol tolerance in mice. They also provide further evidence for the suggestion that GABAnergic synapses may be particularly important in this respect.

The rapid onset of functional tolerance to ethanol--role of different neurotransmitters and synaptosomal membrane lipids. Publishing Authors By Initials

JM Littleton,GR John,PA Jones,SJ Grieve,

For similar organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research

PUBMED ID PMID:

MEDLINE DATE:

The rapid onset of functional tolerance to ethanol--role of different neurotransmitters and synaptosomal membrane lipids. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta psychiatrica Scandinavica. Supplementum

VOLUME: 286

Page Numbers: 137-51

Journal Abbreviation:

ISSN: 0065-1591

DAY: 15

MONTH: 02

YEAR: 1980

The rapid onset of functional tolerance to ethanol--role of different neurotransmitters and synaptosomal membrane lipids. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370365

The rapid onset of functional tolerance to ethanol--role of different neurotransmitters and synaptosomal membrane lipids. Keywords Mesh Terms:

KEYWORDS: gamma-Aminobutyric Acid

MESH TERMS: physiology

Chemical & Substance for Abstract: The rapid onset of functional tolerance to ethanol--role of different neurotransmitters and synaptosomal membrane lipids. Information

Substance Name: Ethanol

Registry Number: 64-17-5

Grant and Affiliation Information for The rapid onset of functional tolerance to ethanol--role of different neurotransmitters and synaptosomal membrane lipids.

AFFILIATION:

Country: DENMARK

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Acta Psychiatr Scand Suppl

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The rapid onset of functional tolerance to ethanol--role of different neurotransmitters and synaptosomal membrane lipids Related Publications

• 25 years of Bayesian methods in the pharmaceutical industry: a personal, statistical bummel.
• Blood free morphine levels vary with concomitant alcohol and benzodiazepine use.
• COLOUR VISION IN THE CONSULTING ROOM.
• COLOUR VISION IN THE CONSULTING ROOM.
• COLOUR VISION IN THE CONSULTING ROOM.
• Discussion of the "White Paper of the PhRMA Working Group on Adaptive Dose-Ranging Designs".
• Dural infiltration of metastatic Hodgkin's lymphoma.
• Elastosis perforans serpiginosa in a patient with renal disease.
• Exophthalmos in rats.
• Flexible design and efficient implementation of adaptive dose-finding studies.
• Frequency Domain Analyses of Neonatal Flash VEP.
• GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving KATP and cAMP.
• Grey-scale ultrasonography and percutaneous transhepatic cholangiography in biliary tract disease.
• Histoplasmosis in Great Britain; description of a second case of disseminated histoplasmosis; treatment by ethyl vanillate.
• Local coherence oscillations in the EEG during development in the fetal baboon.
• Methonium compounds in the treatment of hypertension.
• Sterilisable thermometer for measuring intra-abdominal temperature.
• Survey of west midlands clinical oncology trainees.
• The rapid onset of functional tolerance to ethanol--role of different neurotransmitters and synaptosomal membrane lipids.
• Touch responses made to remembered and visual target locations in the dark: a human psychophysical study.
• Why join a multicentre breast cancer trial?