The RAGE Pathway: Activation and Perpetuation in the Pathogenesis of Diabetic Neuropathy.

The RAGE Pathway: Activation and Perpetuation in the Pathogenesis of Diabetic Neuropathy. Research Abstract Details 

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The RAGE Pathway: Activation and Perpetuation in the Pathogenesis of Diabetic Neuropathy. Abstract Text:

The molecular mechanisms underlying loss of pain perception in diabetic neuropathy are poorly understood. Experimental diabetic neuropathy models recently provided evidence that engagement of the receptor for advanced glycation end products (RAGE) and RAGE-dependent sustained activation of the proinflammatory transcription factor nuclear factor kappa B might significantly contribute to reduced nociception. Most importantly, diabetes-induced loss of pain perception is largely prevented in RAGE-deficient mice compared to RAGE-bearing wild-type mice. Identifying RAGE-dependent inflammation as one pathomechanism underlying neuronal dysfunction might provide the basis for new therapeutic approaches.

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The RAGE Pathway: Activation and Perpetuation in the Pathogenesis of Diabetic Neuropathy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of the New York Academy of Sciences

VOLUME: 1126

Page Numbers: 76-80

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 1

MONTH: Apr

YEAR: 2008

The RAGE Pathway: Activation and Perpetuation in the Pathogenesis of Diabetic Neuropathy. Information

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LANGUAGE: eng

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Grant and Affiliation Information for The RAGE Pathway: Activation and Perpetuation in the Pathogenesis of Diabetic Neuropathy.

AFFILIATION: University of Heidelberg, Department of Medicine I and Clinical Chemistry, INF 410, 69120 Heidelberg, Germany. angelika_bierhaus@med.uni-heidelberg.de.

Country: United States

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MEDLINETA: Ann N Y Acad Sci

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