The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death.

The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death. Research Abstract Details 

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The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death. Abstract Text:

J-H Yim,Y-J Kim,J-H Ko,Y-E Cho,S-M Kim,J-Y Kim,S Lee,J-H Park,J-H Yim,Y-J Kim,J-H Ko,Y-E Cho,S-M Kim,J-Y Kim,S Lee,J-H Park,

Glioma tumor suppressor candidate region gene 2 (GLTSCR2/PICT-1) is localized within the well-known 1.4-Mb tumor suppressive region of chromosome 19q, which is frequently altered in various human tumors, including diffuse gliomas. Aside from its localization on the chromosome, several lines of evidence, such as PTEN phosphorylation, support that GLTSCR2 partakes in the suppression of tumor growth and development. However, much remains unknown about the molecular mechanisms of the tumor suppressive activity of GLTSCR2. The purpose of this study was to investigate the molecular mechanisms of GLTSCR2 in cell death pathways in association with its binding partner PTEN. In this work, we show that GLTSCR2 is a nucleus-localized protein with a discrete globular expression pattern. In addition to phosphorylating PTEN, GLTSCR2 induces caspase-independent PTEN-modulated apoptotic cell death when overexpressed. However, the cytotoxic activity of GLTSCR2 is independent of its ability to phosphorylate PTEN, suggesting that the GLTSCR2-induced cell death pathway is divergent from PTEN-induced death pathways. Our results suggest that the induction of PTEN-modulated apoptosis is one of the putative mechanisms of tumor suppressive activity by GLTSCR2.

The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death. Publishing Authors By Initials

JH Yim,YJ Kim,JH Ko,YE Cho,SM Kim,JY Kim,S Lee,JH Park,JH Yim,YJ Kim,JH Ko,YE Cho,SM Kim,JY Kim,S Lee,JH Park,

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The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell death and differentiation

VOLUME: 14

Page Numbers: 1872-9

Journal Abbreviation: Cell Death Differ.

ISSN: 1350-9047

DAY: 27

MONTH: 07

YEAR: 2007

The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death. Information

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LANGUAGE: eng

NlmUniqueID: 9437445

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Grant and Affiliation Information for The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death.

AFFILIATION: Department of Pathology, College of Medicine, Kyung Hee University, Seoul 130-701, Korea.

Country: England

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MEDLINETA: Cell Death Differ

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