The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response.

The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response. Research Abstract Details 

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The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response. Abstract Text:

Noeet Elitsur,John N Lorenz,Jennifer A Hawkins,Jeffrey A Rudolph,David Witte,Li E Yang,Alicia A McDonough,Mitchell B Cohen,

OBJECTIVES AND METHODS: Guanylin and uroguanylin are peptides synthesized in the intestine and kidney that are postulated to have both paracrine and endocrine functions, forming a potential enteric-renal link to coordinate salt ingestion with natriuresis. To explore the in vivo role of guanylin and uroguanylin in the regulation of sodium excretion, we used gene-targeted mice in which the uroguanylin, guanylin or the peptide receptor guanylate cyclase C gene expression had been ablated. RESULTS: Metabolic balance studies demonstrated that there was impaired excretion of a sodium load in uroguanylin (but not in guanylin or guanylate cyclase C) knockout mice. Uroguanylin-dependent natriuresis occurred without an increase in circulating prouroguanylin. A distinct morphological phenotype was present in the proximal convoluted tubules of uroguanylin knockout animals after an enteral salt loading. Marked vacuolization of the proximal convoluted tubule epithelial cells was observed by using light and electron microscopy. There was also a change in the distribution of the sodium hydrogen exchanger 3 (NHE3) after an enteral salt loading. In wild-type animals, there was a partial redistribution of NHE3 from the villus fraction to the less accessible submicrovillus membrane compartment, but this effect was less apparent in uroguanylin knockout animals, presumably resulting in greater Na/H exchange. CONCLUSIONS: Together, these findings further establish a role for uroguanylin in fluid homeostasis and support a role for uroguanylin as an integral component of a signaling mechanism that mediates changes in Na excretion in response to an enteral salt loading. Proximal tubular NHE3 activity is a possible target for uroguanylin-mediated changes in Na excretion.

The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response. Publishing Authors By Initials

N Elitsur,JN Lorenz,JA Hawkins,JA Rudolph,D Witte,LE Yang,AA McDonough,MB Cohen,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: water-electrolyte balance research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: water-electrolyte balance research

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The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of pediatric gastroenterology and nutritio

VOLUME: 43 Suppl 1

Page Numbers: S74-81

Journal Abbreviation: J. Pediatr. Gastroenterol. Nut

ISSN: 0277-2116

DAY: 3

MONTH: Jul

YEAR: 2006

The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8211545

The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response. Keywords Mesh Terms:

KEYWORDS: Water-Electrolyte Balance

MESH TERMS: drug effects

Chemical & Substance for Abstract: The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response. Information

Substance Name: enterotoxin receptor

Registry Number: EC 4.6.1.2

Grant and Affiliation Information for The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response.

AFFILIATION: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, and the University of Cincinnati, OH 45229, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R24 DK 064403

ACRONYM: DK

MEDLINETA: J Pediatr Gastroenterol Nutr

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