The protein folding problem: a biophysical enigma.

The protein folding problem: a biophysical enigma. Research Abstract Details 

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The protein folding problem: a biophysical enigma. Abstract Text:

Protein folding, the problem of how an amino acid sequence folds into a unique three-dimensional shape, has been a long-standing problem in biology. The success of genome-wide sequencing efforts has increased the interest in understanding the protein folding enigma, because realizing the value of the genomic sequences rests on the accuracy with which the encoded gene products are understood. Although a complete understanding of the kinetics and thermodynamics of protein folding has remained elusive, there has been considerable progress in techniques to predict protein structure from amino acid sequences. The prediction techniques fall into three general classes: comparative modeling, threading and ab initio folding. The current state of research in each of these three areas is reviewed here in detail. Efforts to apply each method to proteome-wide analysis are reviewed, and some of the key technical hurdles that remain are presented. Protein folding technologies, while not yet providing a full understanding of the protein folding process, have clearly progressed to the point of being useful in enabling structure-based annotation of genomic sequences.

The protein folding problem: a biophysical enigma. Publishing Authors By Initials

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: protein folding research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: protein folding research

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The protein folding problem: a biophysical enigma. Journal Published:

PUBLICATION TYPE: Review

Journal: Current pharmaceutical biotechnology

VOLUME: 3

Page Numbers: 329-47

Journal Abbreviation: Curr Pharm Biotechnol

ISSN: 1389-2010

DAY: 12

MONTH: Dec

YEAR: 2002

The protein folding problem: a biophysical enigma. Information

Number of References: 237

LANGUAGE: eng

NlmUniqueID: 100960530

The protein folding problem: a biophysical enigma. Keywords Mesh Terms:

KEYWORDS: Protein Folding

MESH TERMS: trends

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Grant and Affiliation Information for The protein folding problem: a biophysical enigma.

AFFILIATION: GeneFormatics, Incorporated, 5830 Oberlin Drive, Suite 200, San Diego, CA 92121, USA. jacquefetrow@geneformatics.com

Country: Netherlands

AGENCY: United States NIGMS

GRANT: GM 48835

ACRONYM: GM

MEDLINETA: Curr Pharm Biotechnol

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