The promise of nucleic acid vaccines.

The promise of nucleic acid vaccines. Research Abstract Details 

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The promise of nucleic acid vaccines. Abstract Text:

N P Restifo,H Ying,L Hwang,W W Leitner,

Establishing the effective use of 'naked' nucleic acids as vaccines would undoubtedly be one of the most important advances in the history of vaccinology. While nucleic acids show much promise for use as vaccine vectors in experimental animals, not a single naked nucleic acid vector has been approved for use in humans. Indeed, data from human clinical trials is scant: nucleic acid vaccines have not been clearly demonstrated to have any convincing efficacy in the prevention or treatment of infectious disease or cancer. Here we illustrate possible mechanisms underlying effective nucleic acid vaccination. We focus on progress that has been made in the improvement of their function. Additionally, we identify promising new strategies and try to forecast future developments that could lead to the real success of nucleic acid vaccines in the prevention and treatment of human disease.

The promise of nucleic acid vaccines. Publishing Authors By Initials

NP Restifo,H Ying,L Hwang,WW Leitner,

For similar proteins: recombinant proteins: vaccines, synthetic: vaccines, dna research abstracts see: proteins: recombinant proteins: vaccines, synthetic: vaccines, dna research

PUBMED ID PMID:

MEDLINE DATE:

The promise of nucleic acid vaccines. Journal Published:

PUBLICATION TYPE: Review

Journal: Gene therapy

VOLUME: 7

Page Numbers: 89-92

Journal Abbreviation: Gene Ther.

ISSN: 0969-7128

DAY: 28

MONTH: Jan

YEAR: 2000

The promise of nucleic acid vaccines. Information

Number of References: 32

LANGUAGE: eng

NlmUniqueID: 9421525

The promise of nucleic acid vaccines. Keywords Mesh Terms:

KEYWORDS: Vaccines, DNA

MESH TERMS: standards

Chemical & Substance for Abstract: The promise of nucleic acid vaccines. Information

Substance Name: RNA

Registry Number: 63231-63-0

Grant and Affiliation Information for The promise of nucleic acid vaccines.

AFFILIATION: Surgery Branch, National Cancer Institute, Bethesda, MD 20892, USA.

Country: ENGLAND

AGENCY: United States NCI

GRANT: Z01 BC010763-01

ACRONYM: BC

MEDLINETA: Gene Ther

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