The Proline-Rich Sequence of CD3{epsilon} as an Amplifier of Low-Avidity TCR Signaling.

The Proline-Rich Sequence of CD3{epsilon} as an Amplifier of Low-Avidity TCR Signaling. Research Abstract Details 

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The Proline-Rich Sequence of CD3{epsilon} as an Amplifier of Low-Avidity TCR Signaling. Abstract Text:

Engagement of peptide-MHC by the TCR induces a conformational change in CD3epsilon that exposes a proline-rich sequence (PRS) and recruits the cytoskeletal adaptor Nck. This event, which precedes phosphorylation of the CD3epsilon ITAM, has been implicated in synapse formation and T cell function. However, there is compelling evidence that responsiveness to TCR ligation is CD3epsilon PRS independent. In this study, we show that the CD3epsilon PRS is necessary for peptide-MHC-induced phosphorylation of CD3epsilon and for recruitment of protein kinase Ctheta to the immune synapse in differentiated CD8(+) T lymphocytes. However, whereas these two events are dispensable for functional T cell responsiveness to high-avidity ligands, they are required for responsiveness to low-avidity ones. Thus, in at least certain T cell clonotypes, the CD3epsilon PRS amplifies weak TCR signals by promoting synapse formation and CD3epsilon phosphorylation.

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The Proline-Rich Sequence of CD3{epsilon} as an Amplifier of Low-Avidity TCR Signaling. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 181

Page Numbers: 243-55

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Jul

YEAR: 2008

The Proline-Rich Sequence of CD3{epsilon} as an Amplifier of Low-Avidity TCR Signaling. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

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Grant and Affiliation Information for The Proline-Rich Sequence of CD3{epsilon} as an Amplifier of Low-Avidity TCR Signaling.

AFFILIATION: Julia McFarlane Diabetes Research Centre and Departments of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada;

Country: United States

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MEDLINETA: J Immunol

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