[The prognostic significance of regular bone marrow aspirations during induction chemotherapy in acute myeloid leukemia]

[The prognostic significance of regular bone marrow aspirations during induction chemotherapy in acute myeloid leukemia] Research Abstract Details 

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[The prognostic significance of regular bone marrow aspirations during induction chemotherapy in acute myeloid leukemia] Abstract Text:

Y Mi,S Bian,Y Xue,Y Zhao,Q Meng,Y Guo,R Li,T Qin,

OBJECTIVE: To evaluate the prognostic significance of regular aspirations during induction chemotherapy in acute myeloid leukemia. METHODS: Regular bone marrow aspirations were performed during the first course of induction chemotherapy in 96 cases of de novo AML. RESULTS: Complete remission (CR) rate after the first course in patients with < or = 0.10 bone marrow blasts at the 7th day on chemotherapy was higher than that in patients with > 0.10 blasts (64.6% vs 40.0%, P < 0.05). Prolonged the chemotherapy course for a few more days in the latter group of patients increased CR rate from 25.0% to 50.0%. CR rate in patients with < or = 0.10 bone marrow blasts at the nadir of white blood cell count after chemotherapy was higher than that in patients with > 0.10 blasts (66.0% vs 25.8%, P < 0.005), and the refractory cases were significantly fewer in the former group of patients (7.5% vs 45.2%, P < 0.005). CONCLUSION: Regular bone marrow aspirations during induction chemotherapy were helpful in predicting the prognosis and guiding the treatment in AML.

[The prognostic significance of regular bone marrow aspirations during induction chemotherapy in acute myeloid leukemia] Publishing Authors By Initials

Y Mi,S Bian,Y Xue,Y Zhao,Q Meng,Y Guo,R Li,T Qin,

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[The prognostic significance of regular bone marrow aspirations during induction chemotherapy in acute myeloid leukemia] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 18

Page Numbers: 305-7

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 29

MONTH: Jun

YEAR: 1997

[The prognostic significance of regular bone marrow aspirations during induction chemotherapy in acute myeloid leukemia] Information

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LANGUAGE: chi

NlmUniqueID: 8212398

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AFFILIATION: Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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