The prevalence and significance of occult hepatitis B virus in a prospective cohort of HIV-infected patients.

The prevalence and significance of occult hepatitis B virus in a prospective cohort of HIV-infected patients. Research Abstract Details 

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The prevalence and significance of occult hepatitis B virus in a prospective cohort of HIV-infected patients. Abstract Text:

Norah J Shire,Susan D Rouster,Sandra D Stanford,Jason T Blackard,Christina M Martin,Carl J Fichtenbaum,Kenneth E Sherman,

BACKGROUND: Occult hepatitis B virus (HBV) is defined as low-level HBV DNA without hepatitis B surface antigen (HBsAg). Prevalence estimates vary widely. We determined the prevalence of occult HBV at the University of Cincinnati Infectious Diseases Center (IDC). METHODS: Patients in the IDC HIV database (n = 3867) were randomly selected using a 25% sampling fraction. Samples were pooled for HBV nucleic acid extraction. Pools were tested for HBV DNA by a real-time polymerase chain reaction (PCR) assay to co-amplify core/surface protein regions. The PCR assay was run on all individual samples from each DNA pool. DNA samples were tested for HBV serologic markers. RESULTS: A total of 909 patients without known HBV were selected. The mean CD4 count was 384 cells/mm. Forty-three patients were HBV DNA. Twelve of 43 were DNA/HBsAg (95% confidence interval for database: 0.58% to 1.90%). Five of 12 were negative for all serologic markers. Alanine aminotransferase, aspartate aminotransferase, and HBV DNA titers were elevated in HBsAg patients versus occult patients and versus HIV-monoinfected patients. No other significant differences were detected. No occult HBV patient was on treatment with anti-HBV activity. CONCLUSIONS: Forty-three percent of those with HBV were not previously identified as HBV, indicating the need for ongoing screening in high-risk populations. Occult HBV may occur in persons with all negative serologic markers, representing a challenge for identification.

The prevalence and significance of occult hepatitis B virus in a prospective cohort of HIV-infected patients. Publishing Authors By Initials

NJ Shire,SD Rouster,SD Stanford,JT Blackard,CM Martin,CJ Fichtenbaum,KE Sherman,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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The prevalence and significance of occult hepatitis B virus in a prospective cohort of HIV-infected patients. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of acquired immune deficiency syndromes (1

VOLUME: 44

Page Numbers: 309-14

Journal Abbreviation: J. Acquir. Immune Defic. Syndr

ISSN: 1525-4135

DAY: 1

MONTH: Mar

YEAR: 2007

The prevalence and significance of occult hepatitis B virus in a prospective cohort of HIV-infected patients. Information

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LANGUAGE: eng

NlmUniqueID: 100892005

The prevalence and significance of occult hepatitis B virus in a prospective cohort of HIV-infected patients. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: epidemiology

Chemical & Substance for Abstract: The prevalence and significance of occult hepatitis B virus in a prospective cohort of HIV-infected patients. Information

Substance Name: Alanine Transaminase

Registry Number: EC 2.6.1.2

Grant and Affiliation Information for The prevalence and significance of occult hepatitis B virus in a prospective cohort of HIV-infected patients.

AFFILIATION: Division of Digestive Diseases, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA. norah.shire@uc.edu

Country: United States

AGENCY: United States NIAID

GRANT: AI 25897

ACRONYM: AI

MEDLINETA: J Acquir Immune Defic Syndr

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