The preference of tryptophan for membrane interfaces.

The preference of tryptophan for membrane interfaces. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

The preference of tryptophan for membrane interfaces. Abstract Text:

W M Yau,W C Wimley,K Gawrisch,S H White,

One of the ubiquitous features of membrane proteins is the preference of tryptophan and tyrosine residues for membrane surfaces that presumably arises from enhanced stability due to distinct interfacial interactions. The physical basis for this preference is widely believed to arise from amphipathic interactions related to imino group hydrogen bonding and/or dipole interactions. We have examined these and other possibilities for tryptophan's interfacial preference by using 1H magic angle spinning (MAS) chemical shift measurements, two-dimensional (2D) nuclear Overhauser effect spectroscopy (2D-NOESY) 1H MAS NMR, and solid state 2H NMR to study the interactions of four tryptophan analogues with phosphatidylcholine membranes. We find that the analogues reside in the vicinity of the glycerol group where they all cause similar modest changes in acyl chain organization and that hydrocarbon penetration was not increased by reduction of hydrogen bonding or electric dipole interaction ability. These observations rule out simple amphipathic or dipolar interactions as the physical basis for the interfacial preference. More likely, the preference is dominated by tryptophan's flat rigid shape that limits access to the hydrocarbon core and its pi electronic structure and associated quadrupolar moment (aromaticity) that favor residing in the electrostatically complex interface environment.

The preference of tryptophan for membrane interfaces. Publishing Authors By Initials

WM Yau,WC Wimley,K Gawrisch,SH White,

For similar water research abstracts see: water research

PUBMED ID PMID:

MEDLINE DATE:

The preference of tryptophan for membrane interfaces. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biochemistry

VOLUME: 37

Page Numbers: 14713-8

Journal Abbreviation: Biochemistry

ISSN: 0006-2960

DAY: 20

MONTH: Oct

YEAR: 1998

The preference of tryptophan for membrane interfaces. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370623

The preference of tryptophan for membrane interfaces. Keywords Mesh Terms:

KEYWORDS: Water

MESH TERMS: chemistry

Chemical & Substance for Abstract: The preference of tryptophan for membrane interfaces. Information

Substance Name: Water

Registry Number: 7732-18-5

Grant and Affiliation Information for The preference of tryptophan for membrane interfaces.

AFFILIATION: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA.

Country: UNITED STATES

AGENCY: United States NIGMS

GRANT: GM46823

ACRONYM: GM

MEDLINETA: Biochemistry

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

The preference of tryptophan for membrane interfaces Related Publications

• A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility.
• A voltage-sensor water pore.
• Chronic vague abdominal pain in children.
• Cimetidine use and the risk for prostate cancer: results from the VITAL cohort study.
• Do breast cancer risk factors modify the association between hormone therapy and mammographic breast density? (United States).
• Effects of photoperiod and intermittent lighting on reproduction in pheasant hens.
• Exposure to the metabolic inhibitor sodium azide induces stress protein expression and thermotolerance in the nematode Caenorhabditis elegans.
• Extremity trauma research in the United States army.
• Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes.
• Harnessing RNAi for Analyses of Ras Signaling and Transformation.
• In vitro maturation and fertilization of swamp buffalo oocytes and their subsequent development.
• Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma-melanocyte antigen.
• Inhibitory control in children with phenylketonuria.
• Kinetic mechanism of myosinV-S1 using a new fluorescent ATP analogue.
• Mammographic breast density, dense area, and breast area differences by phase in the menstrual cycle.
• PGI2 opens potassium channels in retinal pericytes by cyclic AMP-stimulated, cross-activation of PKG.
• Parachutes and prophylaxis: they both work!
• Polyol synthesis through hydrocarbon oxidation: de novo synthesis of L-galactose.
• Post-thawing survival of motile ram sperm after isolation by layering on protein columns.
• Prevalence of Borrelia burgdorferi in small mammals in New York state.
• Prospects for sexing mammalian sperm edited by Rupert P. Amman and George E. Seidel, Jr.; 288 pages; Cloth - $32.50, Paper - $22.50. Available from Colorado Associated University Press, 1338 Grandview Avenue, Box 480, University of Colorado, Boulder, Colo
• Ras-Sensitive IMP Modulation of the Raf/MEK/ERK Cascade Through KSR1.
• Relationship between estrone sulfate in plasma and litter size at farrowing for sows and gilts.
• Spontaneous baroreflex sensitivity in young and older people during voluntary and electrically evoked isometric exercise.
• Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation.
• The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease.
• The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria.
• The preference of tryptophan for membrane interfaces.
• The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.
• Using verbal fluency to detect very mild dementia of the Alzheimer type.