The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects.

The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects. Research Abstract Details 

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The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects. Abstract Text:

S L Spinelli,J J O'Brien,S Bancos,G M Lehmann,D L Springer,N Blumberg,C W Francis,M B Taubman,R P Phipps,

Historically, platelets were viewed as simple anucleate cells responsible for initiating thrombosis and maintaining hemostasis, but clearly they are also key mediators of inflammation and immune cell activation. An emerging body of evidence links platelet function and thrombosis to vascular inflammation. peroxisome proliferator-activated receptors (PPARs) play a major role in modulating inflammation and, interestingly, PPARs (PPARbeta/delta and PPARgamma) were recently identified in platelets. Additionally, PPAR agonists attenuate platelet activation; an important discovery for two reasons. First, activated platelets are formidable antagonists that initiate and prolong a cascade of events that contribute to cardiovascular disease (CVD) progression. Dampening platelet release of proinflammatory mediators, including CD40 ligand (CD40L, CD154), is essential to hinder this cascade. Second, understanding the biologic importance of platelet PPARs and the mechanism(s) by which PPARs regulate platelet activation will be imperative in designing therapeutic strategies lacking the deleterious or unwanted side effects of current treatment options.

The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects. Publishing Authors By Initials

SL Spinelli,JJ O'Brien,S Bancos,GM Lehmann,DL Springer,N Blumberg,CW Francis,MB Taubman,RP Phipps,

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The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: PPAR research

VOLUME: 2008

Page Numbers: 328172

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ISSN: 1687-4757

DAY: 21

MONTH: 02

YEAR: 2008

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LANGUAGE: eng

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AFFILIATION: Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 608, Rochester,NY 14642,USA.

Country: United States

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MEDLINETA: PPAR Res

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