The possible role of nitric oxide and impaired mitochondrial function in ataxia due to severe vitamin E deficiency.

The possible role of nitric oxide and impaired mitochondrial function in ataxia due to severe vitamin E deficiency. Research Abstract Details 

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The possible role of nitric oxide and impaired mitochondrial function in ataxia due to severe vitamin E deficiency. Abstract Text:

Ataxia due to prolonged vitamin E (RRR-alpha-tocopherol) deficiency still remains the only human neurodegenerative disorder that can be positively attributed to insufficient levels of an essential antioxidant. In affected nerve cells during vitamin E deficiency there is an increase in peroxidation of mitochondrial membranes and a progressive reduction in respiration-dependent axonal transport processes, ultimately resulting in cell death. The possibility of inhibition of electron transport and the increased generation of oxygen radicals that may arise due to prolonged exposure to the toxic nitric oxide radical within mitochondria of vitamin E-deficient neurones is discussed as a pathway to nerve cell death that is characteristically seen in the syndrome.

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The possible role of nitric oxide and impaired mitochondrial function in ataxia due to severe vitamin E deficiency. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Medical hypotheses

VOLUME: 50

Page Numbers: 353-4

Journal Abbreviation: Med. Hypotheses

ISSN: 0306-9877

DAY: 15

MONTH: Apr

YEAR: 1998

The possible role of nitric oxide and impaired mitochondrial function in ataxia due to severe vitamin E deficiency. Information

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LANGUAGE: eng

NlmUniqueID: 7505668

The possible role of nitric oxide and impaired mitochondrial function in ataxia due to severe vitamin E deficiency. Keywords Mesh Terms:

KEYWORDS: Vitamin E Deficiency

MESH TERMS: physiopathology

Chemical & Substance for Abstract: The possible role of nitric oxide and impaired mitochondrial function in ataxia due to severe vitamin E deficiency. Information

Substance Name: Nitric Oxide

Registry Number: 10102-43-9

Grant and Affiliation Information for The possible role of nitric oxide and impaired mitochondrial function in ataxia due to severe vitamin E deficiency.

AFFILIATION: Department of Biological and Chemical Sciences, John Tabor Laboratories, University of Essex, Colchester, UK.

Country: ENGLAND

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MEDLINETA: Med Hypotheses

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