The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis.

The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis. Research Abstract Details 

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The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis. Abstract Text:

Fumi Nakao,Martin L Hudson,Motoshi Suzuki,Zachary Peckler,Rie Kurokawa,Zhicen Liu,Keiko Gengyo-Ando,Akira Nukazuka,Takashi Fujii,Fumikazu Suto,Yukimasa Shibata,Go Shioi,Hajime Fujisawa,Shohei Mitani,Andrew D Chisholm,Shin Takagi,

Semaphorins are extracellular proteins that regulate axon guidance and morphogenesis by interacting with a variety of cell surface receptors. Most semaphorins interact with plexin-containing receptor complexes, although some interact with non-plexin receptors. Class 2 semaphorins are secreted molecules that control axon guidance and epidermal morphogenesis in Drosophila and Caenorhabditis elegans. We show that the C. elegans class 2 semaphorin MAB-20 binds the plexin PLX-2. plx-2 mutations enhance the phenotypes of hypomorphic mab-20 alleles but not those of mab-20 null alleles, indicating that plx-2 and mab-20 act in a common pathway. Both mab-20 and plx-2 mutations affect epidermal morphogenesis during embryonic and in postembryonic development. In both contexts, plx-2 null mutant phenotypes are much less severe than mab-20 null phenotypes, indicating that PLX-2 is not essential for MAB-20 signaling. Mutations in the ephrin efn-4 do not synergize with mab-20, indicating that EFN-4 may act in MAB-20 signaling. EFN-4 and PLX-2 are coexpressed in the late embryonic epidermis where they play redundant roles in MAB-20-dependent cell sorting.

The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis. Publishing Authors By Initials

F Nakao,ML Hudson,M Suzuki,Z Peckler,R Kurokawa,Z Liu,K Gengyo-Ando,A Nukazuka,T Fujii,F Suto,Y Shibata,G Shioi,H Fujisawa,S Mitani,AD Chisholm,S Takagi,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genetics

VOLUME: 176

Page Numbers: 1591-607

Journal Abbreviation: Genetics

ISSN: 0016-6731

DAY: 16

MONTH: 05

YEAR: 2007

The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 374636

The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: metabolism

Chemical & Substance for Abstract: The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis. Information

Substance Name: plexin

Registry Number: 0

Grant and Affiliation Information for The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis.

AFFILIATION: Division of Biological Science, Nagoya University Graduate School of Science, Nagoya, Japan.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM54657

ACRONYM: GM

MEDLINETA: Genetics

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