The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding.

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Research Abstract Details 

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The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Abstract Text:

Haris G Vikis,Weiquan Li,Kun-Liang Guan,

The small GTPase Rac has been implicated in growth cone guidance mediated by semaphorins and their receptors. Here we demonstrate that plexin-B1, a receptor for Semaphorin4D (Sema4D), and p21-activated kinase (PAK) can compete for the interaction with active Rac and plexin-B1 can inhibit Rac-induced PAK activation. We have also demonstrated that expression of active Rac enhances the ability of plexin-B1 to interact with Sema4D. Active Rac stimulates the localization of plexin-B1 to the cell surface. The enhancement in Sema4D binding depends on the ability of Rac to bind plexin-B1. These observations support a model where signaling between Rac and plexin-B1 is bidirectional; Rac modulates plexin-B1 activity and plexin-B1 modulates Rac function.

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Publishing Authors By Initials

HG Vikis,W Li,KL Guan,

For similar enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: rho gtp-binding proteins: rac gtp-binding proteins research abstracts see: enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: rho gtp-binding proteins: rac gtp-binding proteins research

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The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Genes & development

VOLUME: 16

Page Numbers: 836-45

Journal Abbreviation: Genes Dev.

ISSN: 0890-9369

DAY: 1

MONTH: Apr

YEAR: 2002

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8711660

The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Keywords Mesh Terms:

KEYWORDS: rac GTP-Binding Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Information

Substance Name: rac GTP-Binding Proteins

Registry Number: EC 3.6.5.2

Grant and Affiliation Information for The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding.

AFFILIATION: Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

Country: United States

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MEDLINETA: Genes Dev

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