The planarian nanos-like gene Smednos is expressed in germline and eye precursor cells during development and regeneration.

The planarian nanos-like gene Smednos is expressed in germline and eye precursor cells during development and regeneration. Research Abstract Details 

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The planarian nanos-like gene Smednos is expressed in germline and eye precursor cells during development and regeneration. Abstract Text:

Mette Handberg-Thorsager,Emili ,

Planarians are highly regenerative organisms with the ability to remake all their cell types, including the germ cells. The germ cells have been suggested to arise from totipotent neoblasts through epigenetic mechanisms. Nanos is a zinc-finger protein with a widely conserved role in the maintenance of germ cell identity. In this work, we describe the expression of a planarian nanos-like gene Smednos in two kinds of precursor cells namely, primordial germ cells and eye precursor cells, during both development and regeneration of the planarian Schmidtea mediterranea. In sexual planarians, Smednos is expressed in presumptive male primordial germ cells of embryos from stage 8 of embryogenesis and throughout development of the male gonads and in the female primordial germ cells of the ovary. Thus, upon hatching, juvenile planarians do possess primordial germ cells. In the asexual strain, Smednos is expressed in presumptive male and female primordial germ cells. During regeneration, Smednos expression is maintained in the primordial germ cells, and new clusters of Smednos-positive cells appear in the regenerated tissue. Remarkably, during the final stages of development (stage 8 of embryogenesis) and during regeneration of the planarian eye, Smednos is expressed in cells surrounding the differentiating eye cells, possibly corresponding to eye precursor cells. Our results suggest that similar genetic mechanisms might be used to control the differentiation of precursor cells during development and regeneration in planarians.

The planarian nanos-like gene Smednos is expressed in germline and eye precursor cells during development and regeneration. Publishing Authors By Initials

M Handberg-Thorsager,E ,

For similar cells: stem cells research abstracts see: cells: stem cells research

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The planarian nanos-like gene Smednos is expressed in germline and eye precursor cells during development and regeneration. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Development genes and evolution

VOLUME: 217

Page Numbers: 403-11

Journal Abbreviation:

ISSN: 0949-944X

DAY: 28

MONTH: 03

YEAR: 2007

The planarian nanos-like gene Smednos is expressed in germline and eye precursor cells during development and regeneration. Information

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LANGUAGE: eng

NlmUniqueID: 9613264

The planarian nanos-like gene Smednos is expressed in germline and eye precursor cells during development and regeneration. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: metabolism

Chemical & Substance for Abstract: The planarian nanos-like gene Smednos is expressed in germline and eye precursor cells during development and regeneration. Information

Substance Name: RNA-Binding Proteins

Registry Number: 0

Grant and Affiliation Information for The planarian nanos-like gene Smednos is expressed in germline and eye precursor cells during development and regeneration.

AFFILIATION: Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain.

Country: Germany

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MEDLINETA: Dev Genes Evol

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