The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p.

The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p. Research Abstract Details 

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The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p. Abstract Text:

Ruth Nebauer,Irmgard Schuiki,Birgit Kulterer,Zlatko Trajanoski, Daum,Ruth Nebauer,Irmgard Schuiki,Birgit Kulterer,Zlatko Trajanoski, Daum,Ruth Nebauer,Irmgard Schuiki,Birgit Kulterer,Zlatko Trajanoski,Günther Daum,

The majority of phosphatidylethanolamine, an essential component of yeast mitochondria, is synthesized by phosphatidylserine decarboxylase 1 (Psd1p), a component of the inner mitochondrial membrane. Here, we report that deletion of OXA1 encoding an inner mitochondrial membrane protein translocase markedly affects the mitochondrial phosphatidylethanolamine level. In an oxa1Delta mutant, cellular and mitochondrial levels of phosphatidylethanolamine were lowered similar to a mutant with PSD1 deleted, and the rate of phosphatidylethanolamine synthesis by decarboxylation of phosphatidylserine in vivo and in vitro was decreased. This was due to a lower PSD1 transcription rate in the oxa1Delta mutant compared with wild-type and compromised assembly of Psd1p into the inner mitochondrial membrane. Lack of Mba1p, another component involved in the assembly of mitochondrial proteins into the inner mitochondrial membrane, did not affect the amount of phosphatidylethanolamine or the assembly of Psd1p. Deletion of the inner membrane protease Yme1p enhanced Psd1p stability suggesting that Yme1p contributed substantially to the proteolytic turnover of Psd1p in wild-type. In summary, our results demonstrate a link between the mitochondrial protein import machinery, assembly and stability of Psd1p, and phosphatidylethanolamine homeostasis in yeast mitochondria.

The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p. Publishing Authors By Initials

R Nebauer,I Schuiki,B Kulterer,Z Trajanoski,G Daum,R Nebauer,I Schuiki,B Kulterer,Z Trajanoski,G Daum,R Nebauer,I Schuiki,B Kulterer,Z Trajanoski,G Daum,

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The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The FEBS journal

VOLUME: 274

Page Numbers: 6180-90

Journal Abbreviation: FEBS J.

ISSN: 1742-464X

DAY: 1

MONTH: 11

YEAR: 2007

The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p. Information

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LANGUAGE: eng

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Grant and Affiliation Information for The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p.

AFFILIATION: Institute of Biochemistry, Graz University of Technology, Austria.

Country: England

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MEDLINETA: FEBS J

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