The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer.

The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. Research Abstract Details 

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The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. Abstract Text:

R L Dillon,D E White,W J Muller,

The phosphatidyl inositol 3-kinase (PI3K)/Akt pathway is activated downstream of a variety of extracellular signals and activation of this signaling pathway impacts a number of cellular processes including cell growth, proliferation and survival. The alteration of components of this pathway, through either activation of oncogenes or inactivation of tumor suppressors, disrupts a signaling equilibrium and can thus lead to cellular transformation. The frequent dysregulation of the PI3K/Akt pathway in human cancer has made components of this pathway attractive for therapeutic targeting; however, a more comprehensive understanding of the signaling intricacies is necessary to develop pharmacological agents to target not only specific molecules, but also specific functions. Here, we review a series of experiments examining the contribution of molecules of this signaling network including PI3K, phosphatase and tensin homolog deleted on chromosome 10, integrin-linked kinase and Akt and address the significance to human breast cancer.

The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. Publishing Authors By Initials

RL Dillon,DE White,WJ Muller,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. Journal Published:

PUBLICATION TYPE: Review

Journal: Oncogene

VOLUME: 26

Page Numbers: 1338-45

Journal Abbreviation: Oncogene

ISSN: 0950-9232

DAY: 26

MONTH: Feb

YEAR: 2007

The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. Information

Number of References: 81

LANGUAGE: eng

NlmUniqueID: 8711562

The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: metabolism

Chemical & Substance for Abstract: The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. Information

Substance Name: PTEN Phosphohydrolase

Registry Number: EC 3.1.3.67

Grant and Affiliation Information for The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer.

AFFILIATION: Molecular Oncology Group and Departments of Biochemistry and Medicine, McGill University, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada.

Country: England

AGENCY: United States PHS

GRANT: NCI 102036

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MEDLINETA: Oncogene

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