The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria.

The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria. Research Abstract Details 

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The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria. Abstract Text:

Paul N Newton,Karen I Barnes,Peter J Smith,Alicia C Evans,Wirongrong Chierakul,Ronatrai Ruangveerayuth,Nicholas J White,Paul N Newton,Karen I Barnes,Peter J Smith,Alicia C Evans,Wirongrong Chierakul,Ronatrai Ruangveerayuth,Nicholas J White,

OBJECTIVE: Intravenous artesunate is commonly used in the emergency treatment of patients with severe falciparum malaria in Asia. The choice of doses used has been empirical. To inform dosage recommendations we assessed the pharmacokinetics of intravenous artesunate after the first dose. METHODS: As part of a clinical trial of artesunate in adults with severe falciparum malaria in western Thailand, we assayed plasma concentrations of artesunate and the principal biologically active metabolite dihydroartemisinin (DHA) in 17 patients given an initial dose of 2.4 mg/kg body weight of intravenous artesunate. Drug levels were measured using high performance liquid chromatography with mass spectroscopy-electrospray ionisation detection. RESULTS: Median (range) observed DHA Cmax was 2128 (513-5789) nmol/L, elimination half-life was 0.34 (0.14-0.87) h, and the time to the last detectable DHA was 2 h. CONCLUSION: The large inter-individual variability (10 fold) in DHA Cmax and AUC in patients with potentially lethal, severe malaria, suggests that 2.4 mg/kg should be the minimum daily dose in severe malaria.

The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria. Publishing Authors By Initials

PN Newton,KI Barnes,PJ Smith,AC Evans,W Chierakul,R Ruangveerayuth,NJ White,PN Newton,KI Barnes,PJ Smith,AC Evans,W Chierakul,R Ruangveerayuth,NJ White,

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The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of clinical pharmacology

VOLUME: 62

Page Numbers: 1003-9

Journal Abbreviation: Eur. J. Clin. Pharmacol.

ISSN: 0031-6970

DAY: 7

MONTH: 11

YEAR: 2006

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LANGUAGE: eng

NlmUniqueID: 1256165

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AFFILIATION: Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand.

Country: Germany

AGENCY: United Kingdom Wellcome T

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MEDLINETA: Eur J Clin Pharmacol

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