The pathogenesis of gastroesophageal reflux disease.

The pathogenesis of gastroesophageal reflux disease. Research Abstract Details 

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The pathogenesis of gastroesophageal reflux disease. Abstract Text:

W J Dodds,

Reflux disease is a complex process in which different factors may contribute to the final common pathway of esophageal mucosal injury. Individual patients are heterogeneous with respect to the main determinants that contribute to the development of their symptomatic condition. Gastroesophageal reflux occurs by means of several different mechanisms that vary among patients. In many patients, resting LES tone is normal and reflux occurs via transient LES relaxations. In others with a hypotensive LES, acid reflux occurs mainly as stress of free reflux. Only this latter group is likely to exhibit barium reflux during fluoroscopy. Total esophageal exposure to acid material depends on a number of factors, including the rate of reflux, volume and potency of the refluxate, and efficacy of esophageal acid clearance. Abnormal esophageal exposure to acid refluxate depends on increased gastroesophageal reflux, delayed esophageal clearance, or both. Impaired esophageal acid clearance is generally caused by abnormal esophageal motor function that generally can be detected on barium-swallow examination.

The pathogenesis of gastroesophageal reflux disease. Publishing Authors By Initials

WJ Dodds,

For similar natural sciences: physics: pressure research abstracts see: natural sciences: physics: pressure research

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The pathogenesis of gastroesophageal reflux disease. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: AJR. American journal of roentgenology

VOLUME: 151

Page Numbers: 49-56

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ISSN: 0361-803X

DAY: 15

MONTH: Jul

YEAR: 1988

The pathogenesis of gastroesophageal reflux disease. Information

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LANGUAGE: eng

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The pathogenesis of gastroesophageal reflux disease. Keywords Mesh Terms:

KEYWORDS: Pressure

MESH TERMS: radiography

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Grant and Affiliation Information for The pathogenesis of gastroesophageal reflux disease.

AFFILIATION: Department of Radiology and Medicine, Medical College of Wisconsin, Milwaukee 53226.

Country: UNITED STATES

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MEDLINETA: AJR Am J Roentgenol

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