The pathogenesis of club foot. A histomorphometric and immunohistochemical study of fetuses.

The pathogenesis of club foot. A histomorphometric and immunohistochemical study of fetuses. Research Abstract Details 

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The pathogenesis of club foot. A histomorphometric and immunohistochemical study of fetuses. Abstract Text:

K Fukuhara,G Schollmeier,H K Uhthoff,

We studied 16 club feet and 27 normal feet from spontaneously aborted human fetuses in the second trimester of gestation and measured the length of the spring ligament, and the declination angle and size of the talus. We also studied the cellular characteristics of the spring ligament and the immunohistochemical features of the medial ankle ligaments using monoclonal antibodies against type-III collagen, desmin, vimentin, and smooth muscle actin. Histomorphometric results indicated that the talar deformity was not the primary lesion. Histological and immunohistochemical findings showed that the cells and collagen fibres of the medial ankle ligaments of club feet appeared to be the site of the earliest changes, in that they had lost their spatial orientation and had contracted. In severe club feet before the third trimester of gestation, myofibroblast-like cells seemed to create a disorder of the ligaments resembling fibromatosis. This led to contraction and resulted in typical club-foot deformity.

The pathogenesis of club foot. A histomorphometric and immunohistochemical study of fetuses. Publishing Authors By Initials

K Fukuhara,G Schollmeier,HK Uhthoff,

For similar musculoskeletal system: ligaments: ligaments, articular research abstracts see: musculoskeletal system: ligaments: ligaments, articular research

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The pathogenesis of club foot. A histomorphometric and immunohistochemical study of fetuses. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of bone and joint surgery. British vol

VOLUME: 76

Page Numbers: 450-7

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ISSN: 0301-620X

DAY: 14

MONTH: May

YEAR: 1994

The pathogenesis of club foot. A histomorphometric and immunohistochemical study of fetuses. Information

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LANGUAGE: eng

NlmUniqueID: 375355

The pathogenesis of club foot. A histomorphometric and immunohistochemical study of fetuses. Keywords Mesh Terms:

KEYWORDS: Ligaments, Articular

MESH TERMS: metabolism

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Grant and Affiliation Information for The pathogenesis of club foot. A histomorphometric and immunohistochemical study of fetuses.

AFFILIATION: University of Ottawa, Canada.

Country: ENGLAND

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MEDLINETA: J Bone Joint Surg Br

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