The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway.

The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway. Research Abstract Details 

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The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway. Abstract Text:

Lubica Kubikova,Elena A Turner,Erich D Jarvis,

The discrete neural network for songbird vocal communication provides an effective system to study neural mechanisms of learned motor behaviors in vertebrates. This system consists of two pathways--a vocal motor pathway used to produce learned vocalizations and a vocal pallial basal ganglia loop used to learn and modify the vocalizations. However, it is not clear how the loop exerts control over the motor pathway. To study the mechanism, we used expression of the neural activity-induced gene ZENK (or egr-1), which shows singing-regulated expression in a social context-dependent manner: high levels in both pathways when singing undirected and low levels in the lateral part of the loop and in the robust nucleus of the arcopallium (RA) of the motor pathway when singing directed to another animal. Here, we show that there are two parallel interactive parts within the pallial basal ganglia loop, lateral and medial, which modulate singing-driven ZENK expression of the motor pathway nuclei RA and HVC, respectively. Within the loop, the striatal and pallial nuclei appear to have opposing roles; the striatal vocal nucleus lateral AreaX is required for high ZENK expression in its downstream nuclei, particularly during undirected singing, while the pallial vocal lateral magnocellular nucleus of the anterior nidopallium is required for lower expression, particularly during directed singing. These results suggest a dynamic molecular interaction between the basal ganglia pathway and the motor pathway during production of a learned motor behavior.

The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway. Publishing Authors By Initials

L Kubikova,EA Turner,ED Jarvis,

For similar behavior and behavior mechanisms: behavior: behavior, animal: animal communication: vocalization, animal research abstracts see: behavior and behavior mechanisms: behavior: behavior, animal: animal communication: vocalization, animal research

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The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The European journal of neuroscience

VOLUME: 25

Page Numbers: 2145-60

Journal Abbreviation:

ISSN: 0953-816X

DAY: 3

MONTH: Apr

YEAR: 2007

The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway. Information

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LANGUAGE: eng

NlmUniqueID: 8918110

The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway. Keywords Mesh Terms:

KEYWORDS: Vocalization, Animal

MESH TERMS: physiology

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Substance Name: Fluorescent Dyes

Registry Number: 0

Grant and Affiliation Information for The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway.

AFFILIATION: Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, North Carolina 27710, USA. Lubica.Kubikova@savba.sk

Country: France

AGENCY: United States FIC

GRANT: R03TW007615

ACRONYM: TW

MEDLINETA: Eur J Neurosci

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