The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation.

The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Research Abstract Details 

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The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Abstract Text:

Oyetunji A Toogun,Will Zeiger,Brian C Freeman,

Telomeres are the composite of short DNA element tandem arrays and heterotypic protein components that protect and maintain chromosomal termini. As proper telomere maintenance requires a multitude of DNA extension events, it is important to understand the factors that modulate telomerase DNA association. Here, we show that the endogenous levels of the yeast p23 molecular chaperone Sba1p are required for telomere length maintenance and that Sba1p can modulate telomerase DNA binding and extension activities in vitro. Notably, telomere occupancy by telomerase and the extension rate of a shortened telomere fluctuated with changing Sba1 protein levels in vivo. In addition, we found that Sba1p displayed a cell cycle-dependent telomere interaction that paralleled telomerase binding; telomere association by Sba1p depended on its inherent chaperone activity. Taken together, our results support a model in which Sba1p modulates telomerase DNA binding activity for optimal function in vitro and in vivo.

The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Publishing Authors By Initials

OA Toogun,W Zeiger,BC Freeman,

For similar chromosome structures: telomere research abstracts see: chromosome structures: telomere research

PUBMED ID PMID:

MEDLINE DATE:

The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 5765-70

Journal Abbreviation:

ISSN: 0027-8424

DAY: 26

MONTH: 03

YEAR: 2007

The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Keywords Mesh Terms:

KEYWORDS: Telomere

MESH TERMS: metabolism

Chemical & Substance for Abstract: The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Information

Substance Name: Telomerase

Registry Number: EC 2.7.7.49

Grant and Affiliation Information for The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation.

AFFILIATION: Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK074270

ACRONYM: DK

MEDLINETA: Proc Natl Acad Sci U S A

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